摘要
促肾上腺皮质激素释放激素(CRH)是急性高原低氧应激损伤的生物标志物,本文主要探讨在高原低氧应激条件下,CRH在免疫调节中发挥的作用,为高原疾病研究提供依据。以中文医学主题词表(MeSH)词汇"CRH High altitude"和"CRH Immune Cell"检索PubMed数据库;同时,以"促肾上腺皮质激素释放激素"和"免疫细胞"为关键词检索中国知网和万方数据知识服务平台,最终筛选出68篇符合标准的文献。提示,在高原低氧应激下产生的CRH对免疫系统具有抑制作用。这为进一步对高原低氧应激下发生的免疫系统性疾病的诊疗提供了理论基础。
Corticotrophin releasing hormone（ CRH） is a biomarker of stress injury due to acute high altitude hypoxia. In this paper,the role of CRH in immune regulation under conditions of high altitude hypoxia was explored in order to provide a theoretical basis for the study of altitude sickness. We selected 68 articles meeting the inclusion criteria of this study by searching Pub Med database using key words of ＂ CRH High altitude＂ and ＂ CRH Immune Cell＂ included in Me SH,and the databases of CNKY and WANFANG DATA using key words of ＂ 促肾上腺皮质激素释放激素＂ and ＂ 免疫细胞＂. Based on the review of these articles,we concluded that,CRH can inhibit the immune system under conditions of high altitude hypoxia,which provides a theoretical basis for improving the diagnosis and treatment of immune system diseases under conditions of high altitude hypoxia.
出处
《中国全科医学》
CAS
北大核心
2017年第36期4591-4597,共7页
Chinese General Practice
基金
国家自然科学基金资助项目(81360299
81760332)
2015国家级大学生创新创业训练计划资助项目(201510695012)
