脂肪酸在风湿性疾病中的作用

Role of Fatty Acid in Rheumatic Diseases

脂肪酸是由碳、氢、氧三种元素组成的一类化合物,是中性脂肪、磷脂和糖脂的主要成分。饮食中脂肪成分的改变可以引起机体内细胞膜脂肪酸组成的改变,包括细胞免疫系统,而这些变化也可以改变膜的功能,进而影响信号转导。脂肪酸的免疫调节功能参与代谢和免疫之间的相关关系。脂肪酸的种类、结构以及不同脂肪酸的比例可调节机体免疫功能和炎症状态,进而影响风湿性疾病的发生、发展。深入研究脂肪酸的变化在风湿性疾病中的影响,有助于阐明风湿性疾病的发病机制,为治疗风湿性疾病提供新的思路和方法。

Fatty acid is a kind of compound composed of three elements ： carbon, hydrogen and oxygen, and it is the main component of neutral fat, phospholipids and glyeolipids. Changes in the fatty composition of the diet can cause changes in the fatty acid composition of the cell membrane, including cellular immune system, which can also change the function of the membrane and thus affect signal transduction. The immune regulation function of fatty acids is involved in the correlation between metabolism and immunity. The type, structure and proportion of fatty acids can regulate the immune function and inflammatory state of the body, and then affect the occurrence and development of rheumatic diseases. Further study on the changes of fatty acids in rheumatic diseases will help clarify the pathogenesis of rheumatic diseases and provide new ideas and methods for the treatment of rheumatic diseases.