肺癌早期筛查高危人群选择、筛查技术及成本效益的研究进展

Research Progress of Early Screening of Lung Cancer in High Risk Population Selection,Screening Techniques and Cost-Effectiveness

肺癌早期筛查在患者可治愈的阶段发现肺癌,可降低肺癌发病率和病死率。肺癌早期筛查最重要的是确定肺癌高危人群,其次是选择合适的筛查手段,常见的方法有血清生物学标志物、痰细胞学、胸部X线片、低剂量螺旋CT检查等。目前我国肺癌相关致病因子的研究、基层医疗机构诊治条件均与发达国家存在一定差距,同时还缺乏大样本、前瞻性、随机化的筛查成本效益分析研究数据,因此我国肺癌早期筛查策略的制订,需要更多的关注及探索,以便开展更系统的研究。

Early screening for lung cancer at a manageable stage in the patient, can reduce the morbidity and morta- lity. The most important thing in early screening of lung cancer is to identify high-risk groups of lung cancer, followed by the selection of appropriate screening methods, and common methods include serum biomarkers, sputum cytology, chest X-ray, low-dose spiral CT examination etc. At present, there are still some gaps in the research on pathogenic factors related to lung cancer and the diagnosis and treatment condition in primary medical institutions between China and developed countries, at the same time, large sample, prospective and randomized screening cost-effectiveness analysis and research data are still insufficient, therefore, the development of early screening strategies for lung cancer in China needs more attention and explo- ration in order to carry out more systematic research.