p53、EGFR、p16在鼻咽癌中表达的意义

Expression of p53,EGFR and p16 in Nasopharyngeal Carcinoma

目的:观察鼻咽癌组织和鼻咽粘膜慢性炎组织中p53、EGFR、p16蛋白的表达情况,探讨它们在鼻咽癌发生发展中的作用。方法:采用免疫组化SP法检测51例鼻咽癌、27例鼻咽粘膜慢性炎组织中p53、EGFR、p16蛋白的表达。结果:鼻咽癌组织中p53、EGFR的阳性率高于鼻咽粘膜慢性炎组织(P<0.05),p16的阳性率低于鼻咽粘膜慢性炎组织(P<0.05),鼻咽癌组织中p53的表达强弱与年龄、性别、分型、临床分期、淋巴结转移无关(P>0.05)。结论:p53、EGFR蛋白高表达及p16蛋白低表达可能参与鼻咽癌的发生,但p53表达强弱和患者性别、年龄、病理分型、临床分期、淋巴结转移无关。

Objective： To investigate the expression of p53,EGFR,p16 protein in human nasopharyngeal carcinoma（NPC） tissues and the chronic inflammation of nasopharynx mucosa,and to explore their role in the development of nasopharyngeal carcinoma.Methods： Immunohistochemical SP was used to detect the expression of p53,EGFR,and p16 protein in 51 cases of nasopharyngeal carcinoma and 27 cases of nasopharyngeal mucosa chronic inflammation.Results：The positive rates of p53 and EGFR in NPC significantly higher than those in chronic nasopharyngitis tissues（P 〈 0.05）.The positive rate of p16 in NPC significantly lower than that in chronic nasopharyngitis tissues（P 〈 0.05）.The intensity of expression of p53 in nasopharyngeal carcinoma was not related to age,gender,classification,clinical stage and lymph node metastasis（P 〉 0.05）.Conclusion： The high expression of p53 and EGFR protein and the low expression of p16 protein may be involved in the occurrence of NPC.The expression of p53 was not correlated with the gender,age,pathological type,clinical stage and lymph node metastasis of the patients.