新型姜黄素类似物EF24抗癌机制的研究进展

Progress in the Anticancer Mechanism of a New Curcumin Analogue EF24

EF24为一种新合成的新型姜黄素类似物,同样具有广谱抗肿瘤作用,但其抗癌机制仍没有明确定论。本文从EF24抑制NF-κB信号通路、导致细胞增殖周期阻滞、抑制硫氧还蛋白还原酶1、非受体酪氨酸激酶(Src)磷酸化及保护蛋白二硫键异构酶(PDI)、抑制范可尼贫血信号通路等方面,阐述目前EF24抗癌机制的研究进展。

EF24,as a new synthesis of a new type of curcumin analogues,has broad-spectrum antitumor effect,but its anti-cancer mechanism is still not clear.This paper describes the current research progress of mechanism of EF24 from the EF24 inhibition of NF-κB signaling pathway,leading to cell proliferation cycle arrest,the suppression of thioredoxin reductase 1,the phosphorylation of non receptor tyrosine kinase（Src） and protection of two protein disulfide isomerase（PDI）,the inhibition of Fanconi anemia pathway.