丹参注射液与高压氧联合艾地苯醌对血管性痴呆患者血清NPY、TGF-β、HCY水平及生活质量的影响

Effects of salvia miltiorrhiza injection and hyperbaric oxygen combined with idebenone on serum NPY,TGF-βand HCY levels and quality of life in patients with vascular dementia

目的 探讨丹参注射液与高压氧联合艾地苯醌对血管性痴呆（VD）患者血清转化生长因子-β（TGF-β）、同型半胱氨酸（Hcy）、神经肽Y（NPY）水平变化及生活质量的影响.方法 选取66例VD患者,按随机数字表法分为对照组与研究组,每组33例.对照组采用高压氧＋艾地苯醌治疗,研究组采用高压氧＋艾地苯醌＋丹参注射液治疗,两组均持续治疗2个月.疗程结束后统计比较两组临床疗效、不良反应发生率、入院时及疗程结束后生活质量评分（SS-QOL）、日常生活能力评分（ADL）、认知功能评分（MMSE）、血清TGF-β、Hcy、NPY水平变化情况.结果 治疗后两组SS-QOL、ADL、MMSE评分较治疗前增高,且研究组高于对照组,差异有统计学意义（P〈0.05）;两组治疗总有效率比较,研究组[93.94％（31/33）]高于对照组[63.64％（21/33）],差异有统计学意义（P〈0.05）;研究组治疗前血清TGF-β、Hcy、NPY水平与对照组比较,差异未见统计学意义（P〉0.05）,治疗后研究组血清TGF-β水平高于对照组,Hcy、NPY水平低于对照组,差异有统计学意义（P〈0.05）;两组不良反应发生率比较,研究组[12.12％（4/33）]与对照组[6.06％（2/33）]间差异未见统计学意义（P〉0.05）.结论 丹参注射液与高压氧联合艾地苯醌治疗血管性痴呆效果显著,可有效提高血清TGF-β水平,降低Hcy、NPY水平,改善患者认知功能、日常生活能力,提高治疗效果及其生活质量,且具有安全性,值得推广.

Objective To investigate the effects of salvia miltiorrhiza injection and hyperbaric oxygen combined with idebenone on serum transforming growth factor-β （TGF-β）,homocysteine （Hcy）, neuropeptide Y （NPY ） levels and quality of life in patients with vascular dementia （VD ）. Methods Sixty-six patients with VD were divided into control group（n = 33）and study group （n = 33） according to random number table method. The control group were treated with hyperbaric oxygen ＋ ide-benone,and the study group were treated with hyperbaric oxygen ＋ idebenone ＋ salvia miltiorrhiza in-jection,the two groups were treated for 2 months. The clinical efficacy,the incidence of adverse reac-tions,admission and after treatment of stroke specific quality of life scale （SS-QOL）,activity of daily life （ADL）,mini-mental state examination （MMSE）,serum TGF-β,Hcy and NPY levels were statistically compared between the two groups after the course of treatment. Results The SS-QOL,ADL and MMSE scores in the two groups after treatment were higher than those before treatment,and those of the study group were higher than those of the control group,the differences were significant （P 〈 0. 05）;the total effective rate of the study group [93. 94% （31 / 33 ）] was higher than that of the control group （63. 64%,21 / 33）,the difference was significant （P 〈 0. 05）;there was no significant difference in the serum TGF-β,Hcy and NPY levels between the two groups （P 〉 0. 05）,but after treatment,the serum TGF-β level in the study group was significantly higher than that in the control group,and the Hcy and NPY levels were significantly lower than those in the control group （P 〈 0. 05）;there was no significant difference in the incidence of adverse reactions between the study group [12. 12% （4 / 33）]and the con-trol group [6. 06% （2 / 33）]（P 〉 0. 05）. Conclusions Salvia miltiorrhiza injection and hyperbaric ox-ygen combined with idebenone has significant effect on vascular dementia,which can increase the serum TGF-β level,reduce the Hcy and NPY levels,enhance the cognitive function,daily living ability,im-prove the therapeutic effect and life quality,with higher safety,so it is worthy of promotion.