冠心病患者adropin蛋白与同型半胱氨酸水平的相关性研究

Study on correlation between adropin protein and homocysteine level in patients with coronary artery disease

目的探讨冠心病(CAD)患者血清adropin蛋白与同型半胱氨酸(Hcy)水平的相关性,并研究二者与CAD病情严重程度的关系。方法选取2015年8月至2016年10月该院收治的170例CAD患者作为研究对象,收集外周血并检测adropin蛋白、Hcy和其他常规生化指标,检测冠脉病变情况,冠脉病变严重度用SYNTAX评分表示。结果 170例CAD患者Hcy水平为(15.92±8.31)μmol/L,高同型半胱氨酸血症组adropin蛋白水平低于非高同型半胱氨酸血症组,体质量指数、SYNTAX评分和肌酐水平均高于非高同型半胱氨酸血症组,差异有统计学意义(P<0.05)。所有患者SYNTAX评分为(21.51±11.20)分,血清adropin蛋白与Hcy水平呈负相关(r=-0.169,P=0.028);血清Hcy水平与SYNTAX评分无明显相关性(r=0.124,P=0.108);adropin蛋白与SYNTAX评分呈负相关(r=-0.181,P=0.018)。广义结构方程模型显示随着adropin蛋白水平的降低,SYNTAX评分则增加(P=0.019);和不伴有高同型半胱氨酸血症患者比较,伴有高同型半胱氨酸血症患者SYNTAX评分更高(P=0.005)。结论 CAD患者adropin蛋白水平越低,Hcy水平越高,冠脉病变情况则越严重。

Objective To investigate the correlation between serum adropin protein and homocysteine （Hey） level in the patients with coronary artery disease（CAD） and to study their relationship with CAD se-verity. Methods One hundred and seventy cases of CAD in this hospital from August 2015 to October 2016 were selected as the research subjects. Peripheral blood was collected for measuring serum adropin protein, Hey and other conventional biochemical indicators, and the coronary artery lesion was detected by coronary angiography ,the severity of coronary artery lesion was assessed by SYNTAX score. Results In 170 cases of CAD？mean serum Hey level was （15. 92 ± 8. 31）μmol/L,the adropin protein level in the hyperhomocysteinemia group was lower than that in the non-hyperhomocysteinemia group,the difference was statistically significant（P〈0. 05）. Mean SYNTAX score in all cases was （21. 51 ± 11. 20） points,and serum adropin protein was negatively correlated with Hey level （ r =-0. 169 , P = 0. 028）, serum Hey level had no obvious correlation with SYNTAX score （r= 0. 124, P = 0. 108）, the adropin protein level was negatively correlated with SYN-TAX score （r= -0. 181？P = 0. 018）. Generalized structural equation model showed that with the decrease of adropin protein level,the SYNTAX score was increased （P = 0. 019） ,compared with the patients without complicating hyperhomocysteinemia , the SYNTAX score in the patients with hyperhomocysteinemia was much higher（P = 0. 005）. Conclusion The lower the adropin protein level,the higher the Hey level and the severe the coronary artery lesion.