血清Hcy、维生素B12、叶酸水平与阿尔茨海默病的相关性研究

Correlation between Hcy,VitB_(12) and folic acid levels with Alzheimer′s Disease

目的探讨血清同型半胱氨酸(Hcy)、维生素B_(12)(VitB_(12))、叶酸水平与阿尔茨海默病(AD)的相关性。方法通过临床病例整体抽样选取该院AD患者54例作为AD组,另选取同期体检健康者50例作为对照组。分别检测两组血清Hcy、VitB_(12)及叶酸水平并对3项指标间相关性进行分析。结果 AD组血清Hcy水平比对照组显著升高,差异有统计学意义(P<0.05);AD组VitB_(12)及叶酸水平比对照组显著降低,差异有统计学意义(P<0.05)。血清Hcy与VitB_(12)、叶酸呈负相关(r分别为-0.751、-0.807,P<0.05)。AD患者Hcy、VitB_(12)、叶酸及3项指标联合检测受试者工作特征曲线下面积(AUC)分别为0.897、0.176、0.204、0.933。结论Hcy、VitB_(12)及叶酸对AD具有临床诊断价值,3项指标联合检测可提高诊断效能。

Objective To investigate the correlation between the levels of Hcy,VitB_(12) and folic acid with Alzheimer′s Disease(AD).Methods Fifty-four patients with AD in this hospital were extracted as the AD group by using cluster sampling method,and contemporaneous 50 persons undergoing healthy physical examination were selected as the control group.The levels of serum Hcy,VitB_(12) and folic acid were detected in the two groups.Then the correlation among 3 indicators was analyzed.Results Compared with the control group,the level of serum Hcy in the AD group was significantly increased(P<0.05),the VitB_(12) and folic acid levels in the AD group were significantly decreased compared with the control group(P<0.05).The serum Hcy level was negatively correlated with VitB_(12) and folic acid levels(r=-0.751,-0.807,P<0.05).The area under the receiver operating characteristic curves(AUC)of Hcy,VitB_(12) and folic acid and their combine detection in AD patients were 0.897,0.176,0.204 and 0.933 respectively.Conclusion Serum Hcy,VitB_(12) and folic acid have clinical diagnosis value in AD,and the 3-indicator combined detection can increase the diagnosis efficiency.