桥接长段周围神经缺损导管的构建策略

Construction strategy of nerve conduits bridging long peripheral nerve defects

周围神经缺损修复、再生与功能恢复是临床亟待解决的问题,因桥接神经缺损的空腔导管仅具有支撑与隔离的作用,而复合导管能模拟神经再生微环境,具有生物活性,可有效地引导雪旺细胞的迁移和轴突的再生,达到较理想的修复效果和功能恢复.随着组织工程、再生医学和生物材料学以及细胞、分子生物学技术的发展,构建具有仿生性、功能性复合神经导管桥接修复神经长段缺损越来越受到关注.本文就神经导管用于周围神经长段缺损修复的构建策略做以概述.

The repair, regeneration and functional recovery of peripheral nerve defects are the clinical problems needed to be solved urgently.Researches showed that the hollow conduits of bridging nerve defects only had the functions of support and isolation, but the composite conduits could simulate nerve regeneration microenvironment and possess biological activity, which could effectively guide the migration of Schwann cells and the regeneration of axons to achieve satisfactory effects of restoration and functional recovery.With the development of tissue engineering, regenerative medicine, biomaterial and the techniques of cells and molecular biology, the construction of biomimetic and functional nerve conduits to bridge long nerve defects has attracted more and more attention. This review will provide a brief overview of the construction strategy of nerve conduits repairing long nerve defects of peripheral nerves.