细胞因子与支气管哮喘相关性研究

Study on correlation between cytokines and bronchial asthma

支气管哮喘是由多种细胞（如嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞、气道上皮细胞）和各细胞组分参与的气道慢性、高反应性和炎性疾病.细胞因子、黏附分子和一些新近被发现的炎性介质成为了研究的热点.在正常情况下,细胞因子的表达和分泌受机体的严格控制,而在病理状态下,细胞因子及其受体缺陷、细胞因子表达过高或过低.细胞因子分泌后具有调节和决定免疫反应性,它们在介导免疫反应中相互促进或抑制,达到平衡状态.

Bronchial asthma is caused by a variety of cells （such as eosinophils, mast cells, T lymphocytes,neutrophils,airway epithelial cells）and the cellular components involved in chronic airway hyperresponsiveness, and inflammatory diseases. Cytokines, adhesion molecules and some newly discovered inflammatory mediators have become the focus of research. Under normal conditions, the expression and secretion of cytokines are tightly controlled by the body. In pathological conditions, cytokines and their receptors are defective and cytokines are expressed too high or too low. Cytokines secrete and regulate the immune response. And they promote or inhibit each other in the immune response,and reach a balance state.