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14—3—3蛋白与脂代谢的研究进展

Research progress of 14-3-3 protein and lipid metabolism
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摘要 酪氨酸3-加单氧酶/色氨酸5-加单氧酶激活蛋白（14-3-3蛋白）家族是真核细胞中普遍存在、高度保守的酸性蛋白家族,作为一种新型衔接蛋白可与细胞中多种蛋白相互作用参与细胞的多种调节过程,如细胞凋亡、代谢.近年来很多研究发现14-3-3蛋白与许多与脂代谢相关蛋白质相关联,可作为脂代谢紊乱疾病治疗的新靶点.本文主要简述了14-3-3蛋白家族在脂代谢及脂代谢相关疾病中发挥的作用. Tyrosine-3-monooxy genase/tryptophane-5-monooxy-genase activator protein （ 14-3-3 protein ） is a family of highly conservative and widely expressed acidic polypeptides in all eukaryotic cells. The 14-3-3 protein family consists of adaptors and scaffolds that participates in many cellular processes, such as apoptosis and metabolism. Recent studies have found that 14-3-3 protein is associated with many proteins related to lipid metabolism. It could be exploited for therapy of lipid metabolism disorders. This paper briefly describes the role of the 14-3-3 protein in the lipid metabolism and its related diseases.
作者 刘梦丹 祝超瑜 魏丽
机构地区 上海交通大学附属第六人民医院内分泌代谢科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2017年第12期1093-1096,共4页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金面上项目（81570778）
关键词 14—3—3蛋白 脂代谢 14-3-3 protein Lipid metabolism
分类号 R589.2 [医药卫生—内分泌]
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中华内分泌代谢杂志
2017年 第12期

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