益生菌制剂辅助刮治和根面平整对牙周炎疗效的Meta分析

Effect of probiotics combined with scaling and root planing in the treatment of periodontitis: a meta-analysis

目的:分析益生菌制剂联合龈下刮治和根面平整(SRP)的临床效果。方法:系统检索PubMed、Cochrane图书馆、Embase、中国知网以及万方数据库,检索时间截至2017年1月31日,同时查阅相关文献的引文目录。纳入益生菌制剂辅助SRP治疗慢性牙周炎的临床随机对照实验。结果:最终纳入随机对照实验6项,共计患者205例,其中益生菌联合SRP组103例,单纯SRP组102例。Meta分析结果表明,益生菌联合SRP相比单纯SRP可明显降低牙周探诊深度(probing depth,PD)并且增加临床附着水平(clinical attachment level,CAL)。此外,益生菌辅助SRP也可进一步降低慢性牙周炎患者的菌斑指数和牙龈指数,但对探诊后出血百分数无明显影响。结论:在慢性牙周炎的治疗过程中,益生菌辅助SRP的临床疗效优于单纯SRP。

Objective： To compare the clinical efficacy of probiotics combined with subgingival scaling and root planing（ SRP） versus SRP alone in the treatment of chronic periodontitis. Methods： We systematically searched PubMed,The Cochrane Library,Embase,CNKI and Wanfang databases through January 31,2017 and scrutinized the reference lists of relevant literatures. Randomized controlled trials that investigated the clinical effects of probiotics combined with SRP in treating chronic periodontitis were included. Results： Six RCTs were finally included with a total of 205 patients,of whom 103 patients were in the probiotics plus SRP group and 102 patients were in the SRP group. The results of meta-analysis showed that compared with SRP alone,probiotics combined with SRP was associated with a decreased periodontal probing depth（ PD） and an increased clinical attachment level（ CAL）. Moreover,probiotics combined with SRP also further reduced plaque index and gingival index in chronic periodontitis patients,without significant influence on bleeding on probing. Conclusion： In the treatment of chronic periodontitis,probiotics plus SRP has better clinical efficacy compared with SRP alone.