摘要
目的观察致康胶囊联合美沙拉嗪治疗溃疡性结肠炎的疗效,同时通过对患者血清促炎细胞因子(TNF-α,IL-1β和IL-6)和抗炎介质(IL-10)的检测,探讨治疗作用的相关机制。方法选择2013年1月至2016年12月在我院门诊就诊确诊为轻中度溃疡性结肠炎的患者98例。按随机数表法分为两组,每组49例。观察组给予致康胶囊口服3粒/次,3次/d,并美沙拉嗪肠溶片1.0 g/次,4次/d;对照组给予美沙拉嗪肠溶片1.0 g/次,4次/d;两组疗程均为4周。治疗前和治疗后分别检测患者TNF-α、IL-1β、IL-6和IL-10,同时观察和比较两组患者的症状改善情况。结果观察组治疗总有效率为91.84%,对照组为75.51%,两组比较差异有统计学意义(P<0.05)。治疗4周后,观察组TNF-α,IL-1β,IL-6水平分别为(79.22±20.43)ng/L、(16.51±12.72)ng/L、(100.15±24.12)ng/L,较治疗前的(102.55±20.23)ng/L、(31.26±27.63)ng/L、(123.06±25.34)ng/L显著降低,也明显低于对照组治疗后的(97.35±18.39)ng/L、(21.62±14.33)ng/L、(119.01±20.13)ng/L,差异均有统计学意义(P<0.05)。而治疗后观察组患者的IL-10水平为(59.15±7.94)ng/L,明显高于同组治疗前的(21.99±5.14)ng/L和对照组治疗后的(42.51±6.99)ng/L,差异均有统计学意义(P<0.05)。结论致康胶囊联合美沙拉嗪治疗溃疡性结肠炎疗效优于单用美沙拉嗪,其通过降低促炎因子TNF-α、IL-1β和IL-6水平,升高抗炎因子IL-10水平,减轻炎症反应程度。
Objective To observe the curative effect of Zhikang Capsule combined with Mesalazine in the treat-ment of ulcerative colitis, and to explore the mechanism of treatment by detecting the serum levels of proinflammatory cyto-kines(TNF-α, IL-1β and IL-6) and anti-inflammatory mediators(IL-10) in patients. Methods A total of 98 patientswith mild-to-moderate ulcerative colitis in our hospital from January 2013 to December 2016 were enrolled and randomlydivided into two groups. The observation group(49 cases) received Zhikang Capsule(orally, 3 tablets/time, 3 times/day)and Mesalazine enteric-coated tablets(1.0 g/time, 4 times/day). The control group(49 cases) received Mesalazine(1.0 g/time, 4 times/day). The two groups were treated for 4 weeks. The levels of TNF-α, IL-1β, IL-6 and IL-10 were measuredbefore and after treatment, and the symptoms of the two groups were observed and compared. Results The effective rateof treatment was 91.84% in the observation group and 75.51% in the control group(P〈0.05). After treatment for 4 weeks, thelevels of TNF-α, IL-1β and IL-6 in the observation group were(79.22±20.43) ng/L,(16.51±12.72) ng/L,(100.15±24.12) ng/L, significantly lower than(102.55±20.23) ng/L,(31.26±27.63) ng/L,(123.06±25.34) ng/L before treatment in the observa-tion group and the corresponding(97.35±18.39) ng/L,(21.62±14.33) ng/L,(119.01±20.13) ng/L in the control group(P〈0.05). The level of IL-10 in the observation group was(59.15±7.94) ng/L, significantly higher than(21.99±5.14) ng/L be-fore treatment in the observation group and the corresponding(42.51±6.99) ng/L in the control group(P〈0.05). Conclusion Zhikang Capsule combined with Mesalazine for the treatment of ulcerative colitis is better than Methadiazine alone,which can reduce the degree of inflammatory response by reducing the levels of proinflammatory cytokines TNF-α, IL-1βand IL-6 and increasing anti-inflammatory factor IL-10.
出处
《海南医学》
CAS
2017年第23期3820-3822,共3页
Hainan Medical Journal
关键词
溃疡性结肠炎
致康胶囊
美沙拉嗪
促炎细胞因子
抗炎细胞因子
Ulcerative colitis
Zhikang Capsule
Misalazine
Proinflammatory cytokines
Anti-inflammatory factor