NT-proBNP、Hcy、hs-CRP水平与缺血性脑卒中的关联性

Relevance between serum levels of NT-proBNP,Hcy,hs-CRP in patients with acute ischemic stroke

目的探讨N末端前脑钠肽(NT-pro BNP)、同型半胱氨酸(Hcy)及超敏C-反应蛋白(hs-CRP)水平与缺血性脑卒中的关联性。方法将2015年1月至2016年10月来上海交通大学医学院附属新华医院崇明分院门诊和住院的40例缺血性脑卒中患者设为观察组,以同期40例来自医院体检中心的健康志愿者为对照组,分析两组患者的一般资料,比较两组患者之间以及不同梗死体积组患者间的NT-pro BNP、Hcy、hs-CRP水平,并运用多因素Logistic回归模型分析NT-pro BNP、Hcy、hs-CRP水平与缺血性脑卒中的关联性。结果观察组患者中有吸烟史、饮酒史、高血压史、糖尿病史的患者占比分别为12.5%、15.0%、5.0%、2.5%,明显低于对照组的55.0%、40.0%、52.5%、25.0%,差异均有统计学意义(P<0.05);观察组患者的NT-pro BNP、Hcy、hs-CRP水平分别为(631.15±47.22)ng/L、(23.14±4.58)μmol/L、(5.74±1.21)mg/L,均明显高于对照组的(58.62±7.45)ng/L、(8.11±1.15)μmol/L、(2.09±0.59)mg/L,差异均有统计学意义(P<0.05);患者梗死体积越大,NT-pro BNP、Hcy、Hs-CRP水平越高;多因素Logistic回归模型分析结果显示,NT-pro BNP、Hcy、hs-CRP的OR值均有统计学意义(P<0.05)。结论缺血性脑卒中患者通常伴有血清NT-pro BNP、Hcy、hs-CRP水平增加,NT-pro BNP、Hcy、hs-CRP水平可成为反映缺血性脑卒中患者病情变化的指标。

Objective To investigate the association between N terminal-pro brain natriuretic peptide（NT-pro BNP）, homocysteine（Hcy） and high-sensitivity C-reactive protein（hs-CRP） levels and ischemic stroke. Methods Forty patients with ischemic stroke were enrolled in our hospital from January 2015 to October 2016 as observationgroup, and 40 healthy volunteers from the hospital medical examination center were selected as the control group. The lev-els of NT-pro BNP, Hcy and hs-CRP between the two groups and the patients with different infarct volume were compared.Correlation of NT-pro BNP, Hcy and hs-CRP levels and ischemic stroke were analyzed by multivariate logistic regressionmodel. Results The proportion of patients with history of smoking, drinking, hypertension, and diabetes were 12.5%,15.0%, 5.0%, 2.5% in the observation group, significantly lower than the corresponding 55.0%, 40.0%, 52.5%, 25.0% in thecontrol group（P〈0.05）. The levels of NT-pro BNP, Hcy, and hs-CRP were（631.15±47.22） ng/L,（23.14±4.58） μmol/L,（5.74±1.21） mg/L in the observation group, significantly higher than（58.62±7.45） ng/L,（8.11±1.15） μmol/L,（2.09±0.59）mg/L in the control group（P〈0.05）. The larger the infarct volume, the higher the NT-pro BNP, Hcy, hs-CRP levels. The re-sults of multivariate logistic analysis showed that the OR values of NT-pro BNP, Hcy and hs-CRP were statistically signifi-cant（P〈0.05）. Conclusion The level of NT-pro BNP, Hcy, hs-CRP levels in patients with ischemic stroke is usually asso-ciated with an increase in serum levels of NT-pro BNP, Hcy and hs-CRP. NT-pro BNP, Hcy, hs-CRP levels can be an indi-cator of changes in patients with ischemic stroke.