氨甲环酸联合非剥脱点阵激光治疗黄褐斑临床疗效评价

Clinical efficacy of tranexamic acid combined with fractional nonablative laser in the treatment of melasma

目的:评价氨甲环酸联合非剥脱点阵激光治疗黄褐斑的临床疗效。方法:将127例患者分为激光+氨甲环酸组43例、激光组39例,氨甲环酸组45例。非剥脱点阵激光治疗,每月1次,每个受损部位4~5次。氨甲环酸口服250 mg,每日2次,共6个月。结果:治疗后,联合组有效率为90.7%,高于激光组的66.67%和氨甲环酸组的64.44%,差异均有统计学意义(均P<0.05)。联合组症状评分下降指数为0.62±0.08,高于激光组的0.41±0.05和氨甲环酸组的0.39±0.13,差异均有统计学意义(均P<0.05)。结论:氨甲环酸联合非剥脱点阵激光治疗黄褐斑临床疗效优于单用激光或氨甲环酸治疗。

Objective： To assess the efficacy of tranexamic acid combined with fractional non ablative laser in the treatment of melasma. Methods： One hundred and twenty seven patients were randomly divided into tranexamic acid combined with laser group（ 43 patients）,laser group（ 39 patients） and tranexamic acid group（ 45 patients）. The patients in tranexamic acid combined with laser group and laser group were treated with non ablative laser,once a month for 4-5 times. The patients in tranexamic acid combined with laser group and tranexamic acid group were treated with tranexamic acid,250 mg,twice a day for 6 months. Results： The effective rate in the tranexamic acid combined with laser group was 90.7%,which was higher than those in the laser group（ 66.67%） and the tranexamic acid group（ 64.44%）,with significant differences（ P〈0.05）. The decreased index in the tranexamic acid combined with laser group was 0. 62 ± 0. 08,which was higher than that in the laser group（ 0.41±0.05） and the tranexamic acid group（ 0.39±0.13）,with significant differences（ P〈0.05）. Conclusion： The treatment of ranexamic acid combined with fractional non ablative laser is more effective than ranexamic acid or fractional nonablative laser alone in the treatment of melasma.