基于频域分析方法的血栓弹力图凝固过程分析

Analysis of coagulation process based on frequency-domain analysis of thrombelastographic parameters

与常规检测方法相比,血栓弹力图(Thrombelastography,TEG)能够更加快捷、精确观察血小板聚集、凝血、纤溶的整个动态过程进而整体评价凝血功能。但是TEG的评价参数尤为繁多,使得临床医师不能快速有效地判断出患者的病情。本文根据现有的TEG临床评价参数系统,结合TEG的工作原理,利用频域分析方法研究不同类型的TEG图形,探索TEG频域特性,提出频域评价参数,缩减评价参数,为医生判断病情提供一定的指导。结果表明,本文提出的频域参数Fm(频谱最大值)、Δf(频带宽)与K时间、到达最大幅值的时间、α角、最大幅度有一定的相关性,其参数范围能比较直观反应凝固过程的信息,具有确切的生理和病理意义。

Compared with the conventional detection methods, thrombelastography（TEG） allows dynamic observation of the entire process of platelet aggregation, coagulation and fibrinolysis for rapid and accurate evaluation of the overall coagulation function. But the various evaluation parameters of TEG cause much complexity and confusion for the clinicians in making a quick and effective evaluation of the patient＇s condition. Herein we use a frequency-domain analysis-based method for studying different types of TEG patterns by assessing TEG parameters in the context of the working principle of TEG. We also explored the frequency-domain characteristics of TEG and proposed a set of frequency-domain evaluation parameters with a reduced number of TEG parameters to facilitate clinical evaluation of the patient＇s condition. The experimental results showed that the frequencydomain parameter Fm（the maximum spectrum value） and Δf（band width） were correlated with K time, TMA, α angle and the maximum amplitude. The range of the parameters directly reflects the changes in the coagulation process that have physiological and pathological significance.