坦度螺酮联合莫沙必利和雷贝拉唑对反流性食管炎患者氧自由基和炎症因子水平的影响

Effects of combination of tandospirone, mosapride and Bella ray on the levels of oxygen free radicals and inflammatory cytokines in patients with reflux esophagitis

目的 探讨坦度螺酮联合雷贝拉唑对反流性食管炎患者氧自由基和炎症因子水平的影响.方法 选取2016年3月至2017年3月在我院就诊的反流性食管炎90例患者作为研究对象.90例患者根据治疗方式不同分为观察组和对照组,每组45例.观察组患者采用坦度螺酮联合莫沙必利和雷贝拉唑治疗,对照组患者采用莫沙必利联合雷贝拉唑治疗.观察两组患者治疗效果,对比两组患者治疗前后氧自由基和炎症因子水平的差异.结果 治疗后观察组丙二醛（MDA）（16.51±2.6）U/L、晚期氧化蛋白产物（AOPP）（36.5 ± 4.5）μmol/L 明显低于对照组[MDA（20.8 ± 2.9）U/L、AOPP（59.9 ± 4.8） μmol/L],而谷胱甘肽过氧化物酶（GSH-PX）X（249.4±32.3）mg/L、超氧化物歧化酶（SOD）（27.3±3.4） mg/L明显高于对照组[GSH-PX（228.6±17.2）mg/L、SOD（18.8±2.7）mg/L],差异均有统计学意义（t值分别为33.5、32.3、31.4、32.7,P均〈0.05）.治疗后观察组肿瘤坏死因子-α（TNF-α）（17.7±2.8）μg/L、IL（白细胞介素）-6（4.9±0.3）ng/L、IL-8（5.4±0.7）μg/L水平明显低于对照组[（26.3±1.5）μg/L、（6.5 ±1.8）ng/L、（6.6±0.8）μg/L],差异均有统计学意义（t值分别为36.3、31.5、32.4,P均〈0.05）.观察组患者中显效、有效、无效分别为22例、19例、4例有效率91.1%,明显高于对照组患者中显效、有效、无效分别为21例、18例、6例,有效率86.7%,差异有统计学意义（χ2=29.5,P=0.02）.结论 坦度螺酮联合雷贝拉唑有助于降低反流性食管炎患者氧自由基水平和炎症因子水平.

Objective To investigate the effects of combination of tandospirone,mosapride and Bella ray on the levels of oxygen free radicals and inflammatory cytokines in patients with reflux esophagitis.Methods From March 2016 to March 2017,ninety cases with reflux esophagitis treated in Nanchong Central Hospital were involved in this study.The patients were divided into the observation group and the control group according to different treatment methods,45 cases in each group.Patients in the observation group were treated with tandospirone and mosapride combined with ray Bella with treatment,patients in the control group were treated with Mosapride combined with Bella ray,the therapeutic effect of two groups were observed and compared,oxygen free radical and inflammatory cytokines before and after treatment of the two groups were compared.Results After treatment,MDA and AOPP of the patients in the observation group were（16.51±2.6）U/L and（36.5 ±4.5）μmol/L,significantly lower than those in the control group（MDA：（20.8±2.9）U/L,AOPP：（59.9 ±4.8）mol/L）.Glutathione peroxidase（GSH-PX）and superoxide dismutase（SOD）in the observation group were significantly higher than those in the control group（（249.4 ± 32.3）mg/L vs.（228.6 ± 17.2）mg/L, （27.3± 3.4）mg/L vs.（18.8 ± 2.7）mg/L）,the differences were statistically significant（t=33.5,32.3, 31.4.32.7,P〈0.05）.After treatment,the levels of TNF-a,IL-6,IL-8 were significantly lower than those in the control group（17.7±2.8）μg/L vs.（26.3±1.5）μg/L,（4.9±0.3）ng/L vs.（6.5±1.8）ng/L,（5.4±0.7） μg/L vs.（6.6±0.8）μg/L）,the differences were statistically significant（t=36.3,31.5,32.4,P〈0.05）.In the observation group,22 cases were significantly effective,19 cases were effective and 4 cases were ineffective, the effective rate was 91.1%,which was significantly higher than that of the control group（86.7%）,（χ2=29.5,P=0.02）.Conclusion Tandospirone combined with Bella ray can reduce the levels of oxygen free radicals and inflammatory cytokines in patients with reflux esophagitis.