帕金森病的手术治疗研究进展

Advances in surgical treatment of Parkinson＇ s disease

目的 帕金森病（Parkinson＇s Disease,PD）是一种神经退行性疾病,目前仍无有效的治愈手段,其治疗目的主要是控制患者的临床症状并延缓疾病的发展.临床治疗是以左旋多巴为主的药物治疗作为金标准,但长期的药物治疗会导致治疗疗效降低,同时还会出现运动波动、异动症等并发症.近年来,脑深部电刺激术、干细胞移植及基因治疗等手术治疗方法已逐渐在临床中得到广泛应用,其技术也越来越成熟.我们将结合近年相关文献的研究,对PD手术治疗的研究现状与进展进行综述.

Parkinson′s disease（PD）is a neurodegenerative disease,there is no effective means of curative treatment.The purpose of treatment is to control the clinical symptoms of patients and delay the development of the disease.The clinical treatment is based on levodopa-based drug treatment as a gold standard, but long-term drug treatment will reduce the efficacy of treatment,and movement fluctuations,dysmotility and other complications would occur at the same time.In recent years,brain deep electrical stimulation,stem cell transplantation,gene therapy and other surgical treatment have been gradually applied in the clinical practice,the technology become more and more mature.In this paper,based on the recent literature,the study of PD surgical treatment of the status quo and progress were reviewed.