疏风清热解毒方治疗风热袭肺型慢性阻塞性肺疾病急性发作期临床观察

Clinical Observation of Shufeng Qingre Jiedu Prescription for COPD in Acute Exacerbation of Wind-heat Attacking Lung Type

目的:观察疏风清热解毒方治疗风热袭肺型慢性阻塞性肺疾病(COPD)急性发作期的临床疗效。方法:将90例风热袭肺型COPD急性发作期患者随机分为对照组和观察组各45例。对照组给予持续低流量吸氧、维持水电解质平衡、抗炎平喘、化痰止咳等对症治疗,观察组在对照组治疗基础上加用疏风清热解毒方,2组均连续治疗2周。观察2组临床疗效及治疗前后肺功能指标[第1秒最大呼气量(FEV1)、用力肺活量(FVC)和FEV1/FVC值]和动脉血气分析指标[血氧分压(PaO_2)、二氧化碳分压(PaCO_2)]的变化情况。结果:观察组总有效率93.33%,对照组总有效率75.56%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组FVC、FEV1及FEV1/FVC值均较治疗前升高(P<0.05);观察组FVC、FEV1及FEV1/FVC值均高于对照组(P<0.05)。治疗后,2组PaO_2均较治疗前升高(P<0.05),PaCO_2均较治疗前降低(P<0.05);观察组PaO_2高于对照组(P<0.05),PaCO_2低于对照组(P<0.05)。结论:在常规治疗基础上加用疏风清热解毒方可提高风热袭肺型COPD急性发作期患者的临床疗效,增强肺功能和改善动脉血气分析指标。

Objective：To observe the clinical effect of Shufeng Qingre Jiedu prescription for chronic obstructive pulmonary disease（COPD） in acute exacerbation of wind-heat attacking lung type.Methods：Selected 90 cases of patients with COPD in acute exacerbation of wind-heat attacking lung type,and divided them randomly into the control group and the observation group,45 cases in each group.The control group was given continuous low-flow oxygen,maintaining the balance of water and electrolyte,anti-inflammatory and antiasthmatic,resolving phlegm and relieving cough and other symptomatic treatments.The observation group was additionally given Shufeng Qingre Jiedu prescription based on treatment of the control group.Both groups received continuous treatment for 2 weeks.Observed clinical curative effect and changes of indexes of lung function which includes forced expiratory volume at the first second（FEV1）,forced vital capacity（FVC） and value of FEV1/FVC and the changes of index of arterial blood gas analysis which includes partial pressure of Oxygen（PaO_2） and partial pressure of carbon dioxide（PaCO_2） in both groups before and after treatment.Results：The total curative rate was 93.33% in the observation group and was 75.56% in the control group,the difference being significant（P〈0.05）.After treatment,levels of FVC,FEV1 and FEV1/FVC in both groups were higher than those before treatment（P〈0.05）.Levels of FVC,FEV1 and FEV1/FVC in the observation group were higher than those in the control group（P〈0.05）.After treatment,PaO_2 levels in both groups were increased when compared with those before treatment（P〈0.05）,while PaCO_2 levels were decreased（P〈0.05）.PaO_2 levels in the observation group were higher than those in the control group（P〈0.05）,while PaCO_2 levels were lower（P〈0.05）.Conclusion：Based on the routine treatment,additional application of Shufeng Qingre Jiedu prescription can improve the clinical effect,lung functionand index of arterial blood gas analysis of COPD patients in acute exacerbation of wind-heat attacking lung type.