加味升阳汤治疗活动期类风湿性关节炎临床观察及其对胃肠道的影响

Clinical Effect of Jiawei Shengyang Tang in Treating Rheumatoid Arthritis in Active Stage and its Effect on Gastrointestinal Tract

目的:观察加味升阳汤治疗活动期类风湿性关节炎(RA)的临床效果及其对胃肠道的影响。方法:将124例患者随机分为2组各62例,对照组予西药治疗,观察组在对照组治疗方案的基础上加用加味升阳汤治疗,均治疗4周观察疗效,比较2组临床疗效、RA症状改善及胃肠反应情况。结果:2组临床疗效比较,总有效率观察组87.10%,对照组70.97%,差异有统计学意义(P<0.05);治疗4周后,观察组各项关节症状关节疼痛、肿胀数、晨僵时间、压痛数症状变化情况分别与对照组比较,差异均有统计学意义(P<0.05)。胃肠不良反应率观察组1.61%,低于对照组16.13%,差异有统计学意义(P<0.05)。结论:活动期类风湿性关节炎在西药治疗基础上服用加味升阳汤治疗,可有效提高临床疗效,改善风湿病各类症状,且不伤及胃肠道,安全有效。

Objective： To observe the clinical effect of Jiawei Shengyang tang in treating rheumatoid arthritis in active stage and its effect on gastrointestinal tract.Methods：Divided 124 cases of patients into control group and observation group randomly,62 cases in each group.The control group was given western medicine therapy,while the observation group was additionally received Jiawei Shengyang tang therapy,both groups treating for 4 weeks.Observed the clinical effect,improvements of RA and gastrointestinal reaction in both groups.Results ：Comparing the clinical effect in two groups,the total effective rate was 87.10% in the observation group and 70.97% in the control group,the difference being significant（P〈0.05）.After 4 weeks of treatment,compared changes of arthralgia,swelling,morning stiffness time and tenderness and other joint symptoms in the observation group with those in the control group,differences being significant（P〈0.05）.The gastrointestinal adverse reaction in the observation group was 1.61%,being lower than that of 16.13% in the control group,the difference being significant（P〈0.05）.Conclusion：Western medicine combined with Jiawei Shengyang tang in treating rheumatoid arthritis in active stage can effectively improve the clinical effect and various symptoms of rheumatism.It will not cause damage to the gastrointestine,and is safe and effective.