蓝芩颗粒对牙周炎患者炎症因子的影响

Effect of Lanqin Granules on the Inflammatory Factors of Patients with Periodontitis

目的:观察蓝芩颗粒治疗牙周炎患者炎症因子变化的影响。方法:将纳入观察的牙周炎患者共108例随机平分成2组,同时设54名健康成年人为正常组。对照组采用含漱液含漱,观察组在对照组治疗方案的基础上给予蓝芩颗粒。观察比较牙周袋深度(PD)、临床附着丧失量(AL)、龈沟出血指数(BI)和菌斑指数(PLI)、探诊后出血(BOP)等牙周健康指标情况,以及炎症因子C-反应蛋白(CRP)、白细胞介素-6(IL-6)的水平。结果:治疗后,观察组PD、AL、BI、PLI、BOP等牙周健康指标情况分别与治疗前比较,差异均有统计学意义(P<0.05)。2组间各指标分别比较,差异均有统计学意义(P<0.05)。治疗后,2组炎症因子CRP、IL-6分别与治疗前比较,均有下降,差异均有统计学意义(P<0.05);且观察组治疗后炎症因子较对照组明显下降,2组比较,差异均有统计学意义(P<0.05),而与正常组比较,差异无统计学意义(P>0.05)。结论:蓝芩颗粒可以降低牙周炎患者炎症因子水平,有利于牙周炎的炎症控制。

Objective： To observe the effect of Lanqin granules on changes of inflammatory factors of patients with periodontitis.Methods：Averagely divided 108 cases of patients with periodontitis in observation into two groups randomly,and 54 healthy adults were selected as the normal group.Both groups received the treatment of rinsing the oral cavity with gargle,while the observation group additionally received Lanqin granules.Observed and compared the periodontal health indexes such as periodontal depth（PD）,clinical attachment level（AL）,bleeding index（BI） and plague index（PLI） as well as bleeding on probing（BOP）,and the levels of inflammatory factors,C-reactive protein（CRP） and interleukin-6（IL-6）.Results：After the treatment,PD,AL,BI,PLI and BOP were compared with those before treatment,differences being significant（P〈0.05）.All the clinical indicators PD,AL,BI,PLI and BOP in both groups were compared,differences being significant（P〈0.05）.After the treatment,CRP and IL-6 in both groups were decreased when comparing with those before treatment,differences being significant（P〈0.05）; decrease of levels of inflammatory factors in the observation group were more significant when comparing with those of the control group,differences being significant（P〈0.05）;compared with the normal group,there was no significance being found in the differences（P〈0.05）.Conclusion：Lanqin granules can reduce the levels of inflammatory factors of patients with periodontitis,and help control the inflammation of periodontitis.