从郁毒虚论治狼疮性肝损伤

Treatment from Depression,Toxin and Deficiency for Systemic Lupus Erythematosus with Liver Damage

狼疮性肝损伤是系统性红斑狼疮(SLE)病程中常见的并发症,起病隐匿,部分患者仅表现为检验学指标的异常,在临床中未受到足够重视。笔者从中医理论出发,对狼疮性肝损伤的病因病机及诊治思路进行探讨,认为该病以虚为本,以郁为标,气血失和,瘀毒内结,虚实夹杂,交织成疾。治疗应标本兼治,以扶正祛邪为纲,以疏肝调气为要,施以解毒、祛瘀、滋阴之法。随着中医药的干预,中西医结合治疗狼疮性肝损伤有望提高其临床疗效。

Liver damage is a common complication for systemic lupus erythematosus（SLE） with insidious onset,which only manifests in abnormality of laboratory indexes for some patients.Consequently,the disease did not gain enough attention.Based on the theory of Chinese medicine,the authors made a discussion of the etiology and pathogenesis as well as the diagnosis and treatment of SLE with liver damage.The authors thought that the root of the disease was defiency,while symptom presented as depression.Accompanied by disharmony of qi and blood,stagnation of stasis toxin,intermingled deficiency and excess,the disease occured.Treatment for the disease should attach importance to both the root cause and the symptoms,take reinforcing healthy qi and dispelling pathogenic qi as the key link,as well as emphasize on soothing the liver and regulating qi.Thus,therapies of resolving toxins,dispelling stasis and enriching yin should be applied.With the intervention of Chinese medicine,integrated Chinese and western medicine therapy is hopeful to enhance its clinical effect on SLE with liver damage.