柱晶白霉素的生物效价测定及其可靠性测验、误差分析与合并计算

Biological Assay,Reliability Test,Error Analysis and Pooled Calculation for Assessing Leucomycin Yield

本文在运用不同检定菌种、不同检定方法研究和建立柱晶白霉素微生物检定方法的同时,根据生物统计学的原理,以方差分析法对柱晶白霉素的生物检定结果进行可靠性测验与误差分析及其合并计算,将可信限率控制在国际上要求的5％以下。

A biological assay for determining leucomycin yield was established by using a curillinear protocol (Sarcina lutea) and (2.2) dosage or (3.3) dosage protocol (bacillus subtillis 63501). At the same time, according to the prin- ciples of biostatistics and the methods of variance analysis, reliability tests, error analysis and pooled calculations were carried out, so as to hold the confidence limit below the internationally accepted level of 5%.