女贞苷G13、oleonuezhenide与红景天苷的大鼠在体胃肠吸收比较

Comparison of G13,Oleonuezhenide and Salidroside of Rats' Gastrointestinal Absorption

目的:比较女贞子酒蒸前后质变与量变特征化合物(女贞苷G13、oleonuezhenide、红景天苷)的大鼠在体胃肠吸收差异。方法:采用大鼠在体胃肠吸收模型,以HPLC法测定给药后不同时间点大鼠胃和小肠灌注流出液中3种化合物的质量浓度,通过计算吸收速率常数和4 h累计吸收率比较三者在大鼠胃和小肠的吸收差异。结果:女贞苷G13、oleonuezhenide与红景天苷在胃和小肠中的吸收速率常数及4 h累计吸收率的顺序为:红景天苷>oleonuezhenide>女贞苷G13。结论:红景天苷较女贞苷G13、oleonuezhenide更利于胃肠吸收。研究结果为阐明女贞子酒蒸增效机理提供了科学依据。

Objective：To compare the difference among three kinds of characteristic compounds of Ligustrum lucidum Ait （G13, oleonuezhenide, salidroside） in rats＇ gastrointestinal absorption before and after steaming with wine. Methods：Rats in vivo with gastrointestinal perfusion model were used. We determined different time points after treatment of rats stomach and small in- testine perfusion concentration of three kinds of compounds in the effluent quality with HPLC and compared their absorption differences by calculating the absorption rate constant and 4 h cumulative absorption rate. Results ： The sequencing of the Ka and 4 h cumulative absorption in rats＇ stomach and small intestine was salidroside 〉 oleonuezhenide 〉 G13. Conclusion：The salidroside is more conducive to be absorbed by the body compared with G13 and oleonuezhenide. Research result provides a scientific basis for the mechanism of increasing efficiency of Ligustrum lucidum Ait steamed with wine.