摘要
糖尿病肾病（DN）是糖尿病主要的微血管并发症之一,其主要表现为肾小球滤过率增高、基底膜增厚及系膜细胞外基质合成。近年来研究表明多种炎性因子参与了糖尿病肾病的病理改变。炎性因子的分泌和成熟受到NLRP3炎性体的影响和miRNA的调控,其中,NLRP3炎性体在炎症过程中起到了重要作用。文章对NLRP3炎性体在DN炎症机制中的作用进行了综述。
Diabetic nephropathy（DN）is considered as one of the main microvascular complications of diabetes mellitus. The main pathological feasures of DN includes glomerular filtration rate increased,basement membrane thickening and extracellular matrix accumulation. Recent studies have showned that a variety of inflammatory cytokines take part in the pathological changes of diabetic nephropathy. Inflammatory cytokines secretion and maturation affected by NLRP3 inflammasome and the regulation of miRNA and the NLRP3 inflammasome plays an important role in the inflammatory process. This review discusses the role of NLRP3 inflammasome in DN inflammatory mechanisms.
出处
《辽宁中医药大学学报》
CAS
2018年第1期126-129,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课题项目(JDZΧ2015131)
黑龙江中医药大学科研基金项目(035149)
关键词
糖尿病肾病
炎症
NLRP3炎性体
炎性因子
diabetic nephropathy
inflammation
NLRP3 inflammasome
inflammatory cytokines
