雌激素及选择性雌激素受体调节剂对骨关节炎作用的研究进展

Research progresses on the effects of estrogen and selective estrogen receptor modulators on osteoarthritis

目前骨关节炎的发病机制仍未明确,绝经期女性骨关节炎发病率明显升高,这可能与绝经期女性的雌激素减少有关。本文通过研究软骨下骨、软骨和滑膜的病变机制,综述雌激素及选择性雌激素受体调节剂对骨关节炎的影响。

Osteoarthritis,characterized by joint subchondral bone injury,articular cartilage degeneration and aggravation of synovial inflammatory response,is a common chronic and degenerative disease. At present,the pathogenesis of osteoarthritis is still not clear. Some studies have found that the incidence of osteoarthritis in postmenopausal women is significantly higher,which may be related to the decrease of estrogen in postmenopausal women. Therefore,we reviewed the effects of oestrogen and selective estrogen receptor modulator on osteoarthritis,including the pathological mechanism of cartilage,cartilage and synovial lesions.