微小RNA对核受体调控药物代谢酶和转运体的研究现状

Research status of microRNA-dependent control of drug metabolic enzymes and transporters mediated by nuclear receptors

核受体(NRs)是一类配体依赖性转录因子超家族,通过内源性或外源性配体物质激活调控靶基因的转录。核受体在药物代谢酶和转运体的转录调控中发挥着重要的作用。微小RNA(MicroRNA)是一类内源性的具有调控功能的非编码RNA,其对核受体表达的改变可影响药物代谢酶和转运体的表达,进而影响药效、药物不良反应和药物相互作用。本文系统地综述microRNA对几种重要核受体调控药物代谢酶和转运体的影响。

Nuclear receptors（ NRs） is a class of ligand-dependent transcription factor superfamily that regulate the transcription of target genes through endogenous or exogenous ligand activation. Nuclear receptors play an important role in the transcriptional regulation of drug metabolic enzymes and transporters. MicroRNA is a class of endogenous non-coding RNAs with regulatory functions. The control of microRNAs on the expression of nuclear receptors can affect the expression of drug metabolic enzymes and transporters,thus affecting the drug efficacy,adverse drug reactions and drug interactions. This paper systematically reviews the effects of microRNA on the regulation of drug metabolic enzymes and transporters mediated by several important nuclear receptors.