宣肺止咳颗粒的水提醇沉工艺考察

Study on the Water Extraction and Alcohol Precipitation Technology in tegrated of Xuanfei Zhike Granule

目的:优选宣肺止咳颗粒的水提醇沉工艺。方法:以橙皮苷量、射干苷量和干膏得率的综合评分为指标,通过正交试验,考察加水量、煎煮时间、煎煮次数对水提工艺的影响,考察相对密度、醇沉浓度、醇沉时间对醇沉工艺的影响。结果:优选的水提工艺为首次加10倍量水煎煮1.5 h,第2,3次分别加8倍量水煎煮0.5 h;优选的醇沉工艺为水提液浓缩至相对密度1.05(60℃),醇沉至乙醇体积分数80%,冷处静置18 h。结论:优选的提取、醇沉工艺稳定可行,为宣肺止咳颗粒的规范化生产提供参考。

Objective： To optimize the water extraction and alcohol precipitation technology of Xuanfei Zhike granule. Methods： Orthogonal test was used to investigate the effects of adding water, decocting time and boiling time on the water extraction, and the effects of relative density, alcohol precipitation concentration and alcohol prec!pitation time on the alcohol precipitation technology-by taking comprehensive score including the amount of hesperidin, the amount of tectoridin and the yield of dry cream as the indices. Re, suits： The preferred water extraction technology was as follows： added 10 times water and extracted 1.5 h firstly, and then added 8 times water and extracted twice with 0.5 h for each. The preferred alcohol precipitation technology was as follows： concentrated the wa- ter extraction to a relative density of 1.05 （measured at 60℃ ）, slowly added 95% ethanol to 80% alcohol solution and stored 18 h at low temperature. Conclusion： The optimal water extraction and alcohol precipitation technology is stable and feasible, which can pro- vide reference for the standardized production of Xuanfei Zhike granule.