摘要
肾脏是多发性骨髓瘤常见受累器官,应用血液净化技术快速去除血清中的单克隆游离轻链,是药物治疗的重要补充,主要包括血浆置换和高截留量血液透析。基于随机对照研究的结果,血浆置换能否改善肾脏预后仍存在争议。而高截留量血液透析是近年来快速发展的新型治疗模式,一些前瞻性和回顾性研究均显示出其改善肾脏预后的能力。
Renal impairment is common in multiple myeloma. Besides effective chemotherapy,direct removal of serum free light chain by plasmapheresis or high cut-off hemodialysis is also important in the treatment of renal impairment in multiple myeloma. Based on results of the randomized controlled trials,the role of plasmapheresis in treating renal disease of multiple myeloma is debated. On the other side,high cut-off hemodialysis is novel and recently developed. Many studies have shown its potential function to further increase renal response rate when combined with chemotherapy.
出处
《基础医学与临床》
CSCD
2018年第1期112-117,共6页
Basic and Clinical Medicine
