脂肪因子网膜素与动脉粥样硬化的关系

The adipocytokine omentin and its relationship with atherosclerosis

网膜素是由内脏脂肪组织分泌的一种细胞因子,能够增强胰岛素敏感性,与代谢综合征、炎症性疾病等多种疾病密切相关。循环网膜素水平是颈动脉粥样斑块的独立预测因素,表明网膜素可能参与了动脉粥样硬化发生发展的调控。网膜素可能通过内皮细胞保护作用、抑制巨噬细胞源性泡沫细胞形成、抑制血管平滑肌细胞的增殖、迁移、分泌以及抗炎作用发挥着抗动脉粥样硬化作用。文章将对网膜素的生物学特性、生理病理作用以及网膜素与动脉粥样硬化关系的研究进展作一综述。

The newly found adipocytokine omentin,secreted from visceral fat tissue,is reported to have close revelation with metabolic syndrome and inflammatory diseases with the ability of improving insulin sensitivity. As an independent indicator of the existence of carotid atherosclerosis plaque,omentin might regulate the incidence and development of atherosclerosis. Omentin may play an anti-atherosclerosis role by protecting endothelia cells from injuries,inhibiting the formation of macrophage-derived foam cells,suppressing the proliferation,migration and the secreting of smooth muscle cells,as well as its anti-inflammatory effects. This review mainly goes through the papers in terms of omentin and its relationship with atherosclerosis,which may provide a valuable view of atherosclerosis.