胃苏颗粒辅助治疗对慢性胃炎患者胃黏膜环氧化酶-2、钙黏蛋白E表达及血清降钙素原、胃泌素水平的影响

Effect of adjuvant therapy of Weisu Granule on Cyclooxygenase-2,E-cadherin,procalcitonin and gastrin in patients with chronic gastritis

目的:观察胃苏颗粒联合三联疗法(埃索美拉唑、替硝唑和阿莫西林)对慢性胃炎患者胃黏膜环氧化酶-2(COX-2)、钙黏蛋白E(E-cadherin)及血清降钙素原(PCT)、胃泌素水平的影响。方法 :将90例慢性胃炎患者按抽签法随机分为对照组(n=45)和观察组(n=45),两组均行常规治疗。在此基础上,对照组行三联疗法治疗,观察组给予三联疗法联合胃苏颗粒治疗。观察所有受试者治疗前后COX-2、E-cadherin、PCT及胃泌素表达情况。结果:治疗前,两组胃黏膜COX-2和E-cadherin表达水平差异无统计学意义(P>0.05);治疗后,两组COX-2和E-cadherin水平较组内治疗前均显著降低,差异有统计学意义(P<0.05),且观察组低于治疗后对照组,比较差异有统计学意义(P<0.05)。治疗前,两组血清PCT和胃泌素水平比较,差异无统计学意义(P>0.05);治疗后,两组PCT和胃泌素水平较组内治疗前均显著降低,差异有统计学意义(P<0.05),且观察组低于治疗后对照组,比较差异有统计学意义(P<0.05)。结论:胃苏颗粒联合三联疗法治疗慢性胃炎,能有效降低COX-2、E-cadherin、PCT和胃泌素水平,缓解机体胃黏膜损伤,减轻反应症状,是临床有效的治疗方案。

Objective:To observe the effects of Weisu Granule combined with triple therapy(esomeprazole,tinidazole and amoxicillin)on gastric mucosal cyclooxygenase-2(COX-2)and cadherin E(E-cadherin),serum procalcitonin(PCT)and gastrin in patients with chronic gastritis.Methods:Results:There was no significant difference in the levels of gastric mucosal COX-2 and E-cadherin between the two groups before treatment(P>0.05).After treatment,the levels of COX-2 and E-cadherin in both groups were significantly lower than those before treatment(P<0.05).And the observation group was lower than the control group after treatment(P<0.05).There was no significant difference in serum PCT and gastrin levels between the two groups before treatment(P>0.05).After treatment,the levels of PCT and gastrin in both groups were significantly lower than those before treatment(P<0.05).And the observation group was lower than the control group after treatment(P<0.05).Conclusions:Wei Su granule combined with triple therapy in the treatment of chronic gastritis,can effectively reduce the levels of COX-2,E-cadherin,PCT and gastrin,relieve the gastric mucosal injury and symptoms,which is a clinically effective treatment.