多西他赛,奥沙利铂及替吉奥新辅助化疗方案对晚期胃癌患者肿瘤标志物、血管新生及细胞侵袭分子的影响

Docetaxel,oxaliplatin and S-1 in neoadjuvant chemotherapy of markers,angiogenesis and cell invasion of advanced gastric cancer patients with tumor molecular

目的:探讨多西他赛,奥沙利铂与替吉奧新辅助化疗对晚期胃癌患者肿瘤标志物、血管新生及细胞侵袭分子水平的影响。方法:84例晚期胃癌患者依据随机数据表法平均分为对照组(n=42)和观察组(n=42),对照组患者给予多西他赛,奥沙利铂与氟尿嘧啶方案化疗,观察组患者给予多西他赛,奥沙利铂与替吉奧新辅助化疗,比较治疗前后(化疗3个周期后)患者的肿瘤标志物、血管新生及细胞侵袭分子水平。结果:治疗前组间CEA、CA19-9、VEGF、IGF-1、MMP-2和MMP-9水平差异无统计学意义(P>0.05);治疗后两组CEA、CA19-9、VEGF、IGF-1、MMP-2和MMP-9水平均显著低于治疗前,且观察组水平显著低于对照组,差异有统计学意义(P<0.05)。结论:多西他赛,奥沙利铂与替吉奧新辅助化疗治疗晚期胃癌可有效降低患者血清肿瘤标志物水平,抑制血管新生因子及细胞侵袭分子水平释放,具有重要的临床价值。

Objective:To investigate the effect of neoadjuvant chemotherapy of docetaxel,oxaliplatin and S-1 for advanced gastric cancer patients with tumor markers,vascular invasion and cell molecular level in newborn.Methods:A total of84 patients with advanced gastric cancer were randomly divided into control group(n=42)and observation group(n=42)according to the random data table method,patients in the control group were treated with docetaxel,oxaliplatin and fluorouracil chemotherapy,and patients in the observation group were given neoadjuvant chemotherapy with docetaxel,oxaliplatin and S-1,the levels of tumor markers,angiogenesis and cell invasion molecules of the two groups before and after treatment(3 cycles after chemotherapy)were compared Results:there was no significant difference in the levels of CEA,CA19-9,VEGF,IGF-1,MMP-2 and MMP-9 between the two groups before treatment(P>0.05);After treatment,two groups of CEA,CA19-9,VEGF,IGF-1,MMP-2 and MMP-9 were significantly lower than those in the same group before treatment,and the observation group were significantly lower than the control group(P<0.05).Conclusions:Neoadjuvant chemotherapy of docetaxel,oxaliplatin and S-1 for advanced gastric cancer can effectively reduce serum tumor marker levels,inhibition of vascular invasion and cell growth factor release level,has important clinical value.