轻度认知障碍中医体质类型与同型 半胱氨酸水平相关性研究

Study on the Correlation between the Constitution of Chinese Medicine and Homocysteine Levels in Patients of Mild Cognitive Impairment

目的:探讨轻度认知障碍中医体质分布与同型半胱氨酸水平的相关性。方法:收集轻度认知障碍(MCI)患者152例、正常对照组62例,比较其中医体质分布、血清同型半胱氨酸(Hcy)水平,运用logistics回归分析方法分析MCI常见中医体质及其相关的Hcy异常升高在MCI发病中的影响。结果:(1)两组间平和质、偏颇体质及其体质类型构成的比较存在显著差异(P<0.01);(2)两组间的血清Hcy水平及Hcy异常率差异有统计学意义(P<0.05);(3)两组Hcy水平正常者的体质构成比没有差异(P>0.05);两组Hcy异常升高者的体质构成比存在差异(P<0.05);(4)logistics回归分析:阳虚质、痰湿质、瘀血质三种体质发生MCI危险性明显高于其他体质,此三种体质及Hcy异常升高与罹患MCI有相关性(P<0.05),平和质和气虚质与发生MCI呈负相关。结论:平和质、气虚质可能是MCI的保护体质;MCI患者的Hcy水平及Hcy异常升高率均比正常人群高;MCI人群中痰湿质、瘀血质、阳虚质三种体质的Hcy异常升高率高于其他体质人群,为MCI易感体质;痰湿质、瘀血质、阳虚质以及Hcy异常升高是导致MCI的危险因素。

Objective: To investigate the correlation between the distribution of Chinese Medicine(CM)constitution and homocysteine levels in patients of mild cognitive impairment. Methods: One-hundred and fifty-two cases of mild cognitive impairment(Mild cognitive impairment,MCI)and 62 cases of non MCI Normal controls(Normal control,NC)were classified according to the constitution of CM and detected the level of homocysteine(Homocystein,Hcy). The method of logistics regression analysis was used to analyze the influence of common CM constitution of MCI patients and abnormal increase of related Hcy in pathogenesis of MCI patients. Results:(1) There was a significant difference between the two groups in the distribution ratio of the moderate constitution,partial constitution and the type of constitution(P< 0.01);(2)The difference of the serum Hcy levels and Hcy abnormal rate between the two groups were of statistical significance(P<0.05);(3)There was no difference in the constituent ratios of Hcy normal patients between the two groups(P>0.05);There was a significant difference in the constituent ratios of patients with Hcy abnormal increase between the two groups(P<0.05);(4)Logistics regression analysis: The risk of MCI occurrence in Yang deficiency,phlegmdampness,and blood stasis pattern is significantly higher than that of other constitutions. The three kinds of constitution and abnormal increase of Hcy level had a correlation with the occurrence of MCI(P<0.05);Moderate constitution and qi deficiency pattern were negatively correlated with the occurrence of MCI. Conclusions: Moderate and qi deficiency constitution could be protective for MCI;Hcy levels and Hcy abnormal rate in patients with MCI is higher than the NC group;The patterns of Yang deficiency,phlegm dampness,and blood stasis are the MCI susceptible constitution and the Hcy abnormal increase of them is higher than that of other constitutions in patients with MCI;Yang deficiency,phlegm dampness,blood stasis and the abnormal increase of Hcy are the risk factors for the occurrence of MCI.