超高分辨率光学相干断层扫描在眼前节的应用进展

Application of ultrahigh-resolution optical coherence tomography in anterior segment of ocular

作为一项非接触、无创的组织结构成像技术,光学相干断层扫描(optical coherence tomography,OCT)系统可对眼组织高分辨率成像。最初应用于眼后节组织结构成像,随后逐渐应用于眼前节。眼前节OCT技术的发展确保眼前节组织结构精准成像。近来提出的超高分辨率OCT(ultrahigh-resolution OCT,UHR-OCT)技术,实现了对眼前节各层次组织结构超高分辨成像,并成功应用于眼前节及眼表疾病的诊治。如定量测量干眼症患者泪膜厚度值,鉴别诊断眼表鳞状上皮瘤样增生性病变,监测各类角膜炎、圆锥角膜、角膜外伤等角膜疾病的病理生理变化趋势。同时,UHR-OCT亦可协助临床工作者制定合理的眼前节手术方案,如角膜移植术,并追踪观察术后角膜组织愈合等形态学变化情况。此外,该技术加深了对眼前节组织结构生理及病理生理形态学的了解。本文主要对UHR-OCT的技术原理及在眼前节应用进展等进行综述。

Optical coherence tomography(O C T),as a noncontact, innovative technology,can produce high-resolution images of ocular tissues. This technology is originally used for posterior segment in ophthalmology,w hich w ere w idely utilized for the anterior segment at first. The development of anterior segment OCT( AS-O C T) technology enables the precise visualization of anterior segment structure. M oreover,ultrahigh-resolution O C T( UHRO C T) has been helpful for diagnosis and management of corneal and anterior segment diseases, including quantification of tear film for dry eye,authentication of ocular surface squamous neoplasia( O SSN),pterygium,keratoconus,traumatic corneal injuries,etc. Besides,UHR-O C T can be also used for planning and performing surgery for anterior segment,such as corneal transplantation,and monitoring of epithelial wound healing and postoperative course as w ell. Moreover,this technology can help understand the physiology and pathophysiology of the anterior segment structure. T herefore,this review will give a review on the application of UHR-O C T for diagnosis and management of corneal and anterior segment disorders.