肝癌的多模式治疗

Multimodal treatment of hepatocellular carcinoma

原发性肝癌是最常见的肝癌,发病率逐年上升,目前已成为全世界癌症相关死亡的第三大病因。尽管原发性肝癌的临床诊断和治疗在过去的几十年中显著改善,但是其预后仍然较差。我们依据巴塞罗那分期系统,不同的外科手术、放射超声介入和非介入治疗被确定为肝癌的多模式治疗。BCLC系统被用来作为决策指南,但是它在决定患者治疗方法方面有一定的局限性,我们应该为每个患者提供个体化的治疗,而不是完全根据指南确定。本篇综述对目前肝癌的常见治疗进行总结。

Hepatocellular carcinoma(HCC)represents the most common liver cancer with an increasing incidence and it accounts for the third most common cause of cancer-related death worldwide.Even though the clinical diagnosis and management of HCC improved significantly in the last decades,this malignant disease is still associated with a poor prognosis. Based on Barcelona-Clinic Liver Cancer(BCLC)staging system different surgical,interventional radiological/sonographical and non-interventional procedures have been established for the multimodal treatment of HCC. The BCLC classification system represents a decision guidance;however because of its limitations in selected patients treatment allocation should be determined on an individualized rather than a guideline-based medicine by a multidisciplinary board in order to offer the best treatment option for each patient. This review summarizes the current management of HCC.