Eph A5在卵巢癌组织中的表达及与临床特征和预后的关系

Expression of Eph A5 in ovarian carcinoma and its relationship with clinical features and prognosis of patients

目的探讨浆液性卵巢癌组织中酪氨酸蛋白激酶A5受体(Eph A5)的表达水平变化、与患者临床病理学特征及预后的关系。方法浆液性卵巢癌病理组织标本94例作为恶性组、选取同期收集的卵巢浆液性囊腺瘤组织标本30例作为良性组,采用免疫组化染色观察2组标本中Eph A5蛋白表达差异,并采用Logistic回归分析浆液性卵巢癌患者的预后影响因素。结果恶性组的Eph A5蛋白阳性表达率高于良性组(P<0.05);浆液性卵巢癌组织中Eph A5蛋白表达与肿瘤分化程度、FIGO分期、淋巴结转移具有相关性(P<0.05);Eph A5蛋白阳性表达的浆液性卵巢癌患者3年生存率高于阴性表达患者(P<0.05);Eph A5蛋白阳性表达对浆液性卵巢癌患者远期预后有利(OR=0.629,P<0.05),低分化、FIGO分期增高、淋巴结转移时患者远期预后的不良因素(OR=1.833,OR=1.467,OR=1.625,P<0.05)。结论浆液性卵巢癌组织中Eph A5蛋白的表达水平上调,与患者的肿瘤分化程度、FIGO分期、淋巴结转移具有相关性,是患者远期预后的保护因素。

Objective To investigate the expression of tyrosine kinase A5 receptor（ Eph A5） in serous ovarian cancer tissues and its relationship with clinicopathological features and prognosis of patients. Methods Ninety-four cases of serous ovarian cancer tissues collected in our hospital from January 2010 to December 2013 were enrolled as malignant group,meanwhile,30 cases of ovarian serous cystadenoma tissues were served as benign group. The expression levels of Eph A5 protein were detected by immunohistochemical staining for both groups,moreover the influencing factors on prognosis of patients with serous ovarian cancer were analyzed by Logistic regression analysis. Results The positive expression rate of Eph A5 protein in malignant group was 74. 47%,which was significatly higher than that（ 6. 67%） in benign group（ P〈0. 05）,moreover,the expression levels of Eph A5 protein in serous ovarian cancer tissues were closely correlated to tumor differentiation degree,FIGO stage and lymph node metastasis（ P〈0. 05）. The 3-year survival rate in patients with positive expression of Eph A5 protein was 65. 71%,which was significantly higher than that（ 41. 67%） in patients with negative expression of Eph A5 protein P〈0. 05）. The positive expression of Eph A5 protein was beneficial for the long-term prognosis of patients with serous ovarian cancer（ OR = 0. 629,P〈0. 05）,however,lower differentiation,higher FIGO stage and lymph node metastasis were adverse factors influencing long-term prognosis of patients（ OR = 1. 833,1. 467,1. 625,respectively,P〈0. 05）. Conclusion The up-regulation of expression levels of Eph A5 protein in serous ovarian carcinoma tissues is closely correlated to tumor differentiation degree,FIGO stage and lymph node metastasis,which is a protective factor of long-term prognosis of patients.