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双调蛋白及其在气道炎性疾病中作用的研究进展 被引量：1

Research progress of amphiregulin and its role in airway inflammatory disease
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摘要 1988年,AREG被Shoyab等在经12-肉豆蔻酸-13乙酸佛波醇处理后的人乳腺癌MCF-7细胞系上清液中首次发现,由于其既可以促进角质细胞、成纤维细胞的增殖,又可以抑制一些肿瘤细胞系的生长,因此被命名为＂双调蛋白＂。 Amphiregulin is a member of epidermal growth factor family,and is also one of the ligand of epidermal growth factor receptor,it participates in many physiological and pathological process by combining with EGFR.Researches have proved that AREG participates in asthma and airway inflammatory diseases caused by smoking and PM 2.5,and AREG plays an important role in the process of airway remodeling and inflammation.This paper mainly reviews the expression and function of AREG,and focus on its research status in airway inflammatory disease.
作者 高玲 许昱
机构地区 武汉大学人民医院耳鼻咽喉头颈外科
出处 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2018年第1期77-80,共4页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金 国家自然科学基金面上项目(No:81770986 No:81371070) 湖北省自然科学基金项目(No:2015CKB756)
关键词 双调蛋白 气道炎性疾病 amphiregulin epidermal growth factor receptor airway inflammation asthma
分类号 R764 [医药卫生—耳鼻咽喉科]
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  • 1Shoyab M, McDonald VL, Bradley JG, et al. Amphiregulin: a biftmctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adeno- carcinoma cell line Mcf-7. Proc Natl Acad Sci U S A, 1988, 85 (17):6528-32.
  • 2Conti M, Hsieh M, Park JY, et al. Role of the epidermal growth factor network in ovarian follicles. Mol Endocrinol, 2006, 20(4): 715-23.
  • 3Sebio A, Paez D, Salazar J, et al. Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan. Pharmacogenomics J, 2014, 14(3):256-62.
  • 4Levano KS, Kenny PA. Clarification of the C-terminal proteolytic processing site of human amphiregulin. FEBS Lett, 2012, 586 (19):3500-2.
  • 5Busser B, Sancey L, Brambilla E, et al. The multiple roles of amphiregulin in human cancer. Biochim Biophys Acta, 2011, 1816(2):119-31.
  • 6Ciarloni L, MallepeU S, Brisken C. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A, 2007, 104(13): 5455-60.
  • 7Shiraishi K, Matsuyama H. Local expression of epidermal growth factor-like growth factors in human testis and its role in spermatogenesis. J Androl, 2012, 33(1):66-73.
  • 8Zhou Y, Lee JY, Lee CM, et al. Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-beta-induced pulmonary fibrosis. J Biol Chem, 2012, 287(50):41991-2000.
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临床耳鼻咽喉头颈外科杂志
2018年 第1期

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