2015年河北省耐药监测网肠球菌属细菌耐药性监测

Antimicrobial resistance of Enterococcus sppin Hebei antimicrobial resistance surveillance net in 2015

目的了解河北省肠球菌属细菌的分布及耐药性,为医院感染控制提供可靠依据。方法收集2015年1月1日-12月31日河北省耐药监测网51所医院检出的肠球菌属细菌;采用仪器法进行菌株鉴定,Kirby-Bauer纸片法或仪器法进行药敏试验;采用WHONET5.6软件进行统计分析。结果河北省51所医院共分离肠球菌属细菌4 159株,其中屎肠球菌2 258株占54.3%,粪肠球菌1 575株占37.9%,鸟肠球菌95株占2.3%,鹑鸡肠球菌86株占2.1%,铅黄肠球菌64株占1.5%,鸽肠球菌51株占1.2%,其他菌30株占0.7%;粪肠球菌对万古霉素的耐药率最低为0.9%,对红霉素耐药率最高为74.5%;屎肠球菌对万古霉素的耐药率为2.4%,对红霉素耐药率为87.7%;此外,分离自尿液标本和非尿液标本的肠球菌属耐药率有明显差异。结论临床肠球菌属感染以屎肠球菌和粪肠球菌为主,耐药现状严重,临床应结合具体药敏结果合理使用抗菌药物。

OBJECTIVE To understand the distribution and drug resistance of Enterococcus spp strains in Hebei province so as to provide reliable basis for control of nosocomial infections. METHODS The Enterococcus spp strains that were isolated from 51 hospitals under Hebei antimicrobial resistance surveillance net were collected form Jan 1, 2015 to Dec 31, 2015, the strains were identified by using instrument method, the drug susceptibility testing was carried out with the use of Kirby-Bauer disk method or instrument method, and the statistical analysis was performed by means of WHONETS.6 software.RESULTS A total of 4159 strains of Enterococcus spp were isolated from the 51 hospitals in Hebei province, of which 2258 （54.3%） were Enterococcus faecium, 1575 （37.9~） were Enterococcus faecalis, 95 （2.3%） were Enterococcus aviurn, 86（2.1%） were Enterococcus galli- nature, 64 （1.5%） were Enterococcus casseliflavus, 51 （1.2~） were Enterococcus columbae, and 30 （0.7%） were other species.The drug resistance rate of the E.faecalis strains to vancomycin was the lowest （0.9%）, and the drug resistance rate to erythromycin was the highest （74.5%）; the drug resistance rate of the E.faecium strains to vancomycin was 2.4%, and the drug resistance rate to erythromycin was 87.7% ; in addition, there was significant difference in the drug resistance rate between the Enterococcus strains isolated from urine specimens and the strains isolated from non-urine specimens.CONCLUSION The E.faecium and E.faecalis are the predominant species of Enterococcus causing the clinical infections and are highly resistant to antibiotics.It is necessary for thehospital to reasonably use antibiotics based on the result of the drug susceptibility testing.