药物代谢酶和转运体介导的辣椒素-药物相互作用研究进展

Advances in Metabolizing Enzymes and Transporters Mediated Capsaicin-Drug Interaction

随着辣椒素的临床研究不断深入,辣椒素-药物相互作用问题日益凸显。近年来的研究结果显示,辣椒素对多种药物代谢酶和转运体有显著的诱导或抑制作用,通过多种因素影响合用药物的体内过程,进而导致复杂的药物相互作用的发生。笔者查阅了近几年国内外相关研究,从辣椒素对药物代谢酶及转运体的调控作用等方面进行综述,预测可能与辣椒素发生显著相互作用的药物,以期为临床合理用药提供理论指导,同时为复杂的药物相互作用提供新的研究思路。

With the continuously clinical study of capsaicin, capsaicin-drug interaction has become increasingly prominent. In recent years, the studies indicate that capsaicin shows a significant inducing or inhibitory effect on a variety of drug metabolism enzymes and transporters, thereby leading to the occurrence of complex drug interactions and affecting the other drugs in vivo process. In this paper, the modulation effect of capsaicin on drug metabolizing enzymes and transporters by reviewing the relevant research at home and abroad in recent years were summarized, and the drug-drug interactions associated with capsaicin in order to provide theoretical guidance for clinical rational drug use were explored. Furthermore, complex drug-drug interaction studies can be provided with prior examples.