眼底自身荧光在非感染性葡萄膜炎中的应用研究现状及进展

The status and advances in the application of fundus autofluorescence in noninfectious uveitis

非感染性葡萄膜炎是指除外感染因素及伪装综合征的一类累及葡萄膜的炎症性疾病。其中累及视网膜、脉络膜的非感染性葡萄膜炎的诊断及随访依赖眼底影像检查。眼底自身荧光是一项非侵入性的眼底成像技术。相较于眼底彩色照相、荧光素眼底血管造影、吲哚青绿血管造影等检查，眼底自身荧光能更好地提示视网膜色素上皮和光感受器细胞的功能状态。其在Vogt-Koyanagi-Harada综合征、Beh？et病、多灶性脉络膜炎、点状内层脉络膜病变、鸟枪弹样脉络膜视网膜病变、多发性一过性白点综合征、急性区域性隐匿性外层视网膜病变、急性后部多灶性鳞状色素上皮病变、匍匐性脉络膜炎等非感染性葡萄膜炎的发病机制研究、早期诊断、病情监测、预后评估中有一定作用。

Noninfectious uveitis refers to a category of inflammatory diseases involving the uvea, with the exception of infectious factors or masquerade syndrome. The diagnosis and follow-up of noninfectious uveitis that involving retina or choroid require fundus imaging techniques. Fundus autofluorescence is a noninvasive imaging technique. Compared with fundus colorized photography, fundus fluorescein angiography and indocyanine green angiography, fundus autofluorescence indicates the functional status of retinal pigment epithelium and photoreceptor cells in a better way, thus playing a role in the pathophysiological mechanisms investigating, early diagnosis, disease progression monitoring and prognosis estimating of noninfectious uveitis, such as Vogt-Koyanagi-Harada disease, Beh？et disease, multifocal choroiditis, punctate inner choroidopathy, birdshot chorioretinopathy, multiple evanescent white dot syndrome, acute zonal occult outer retinopathy, acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis.