体检人群中代谢综合征与QTc间期延长的相关性研究

Association between metabolic syndrome with QTc interval prolongation in physical examination subjects

目的探讨代谢综合征(MS)与校正的QT(QTc)间期延长的关系。方法选取2015年6月至2016年6月该院18岁以上体检行心电图检查者1 260例,根据有无MS分为MS组与Non-MS组。按照Bazett公式计算QTc间期。建立Logistic回归模型,分析MS与QTc间期延长的关系。结果 MS组QTc间期延长者63例,Non-MS组40例(P<0.01)。在未调整模型中,MS是QTc间期延长的危险因素[OR=6.36,95%CI(2.34,8.67),P<0.01]。进一步调整混杂因素后,MS与QTc间期延长仍密切相关[OR=4.11,95%CI(2.09,7.13),P<0.01]。在MS各组分别与QTc间期延长的关系研究中,调整混杂因素后,仅腹型肥胖[OR=2.76,95%CI(1.43,7.56),P<0.01]及高三酰甘油血症[OR=1.75,95%CI(1.22,4.31),P=0.013]与QTc间期延长密切相关。结论 MS是QTc间期延长的独立危险因素,应加强对MS患者血脂及腹围的管理。

Objective TO explore the relationship between metabolic syndrome（MS） and corrected QT（QTc） interval prolongation. Methods A total of 1 260 participants having electrocardiogram examinations,aged over 18 years old from June 2015 to June 2016 were included and divided into the MS group and non-MS group. QTc was calculated according to the Bazett formula. The Logistic regression model was established for exploring the association between MS and QTc. Results There were 63 cases of QTc interval prolongation in the MS group,however,40 cases in the non-MS group（P〈0.01）. In the unadjusted model,MS was a risk factor of QTc interval prolongation[OR= 6.36,95%CI（2. 34,8.67）, P〈0.01]. After further adjusting confounders, MS was still correlated with QTc interval prolongation[OR=4.11,95%CI（2.09,7.13 ,P〈0. 01]. In the study of the relationship between the MS groups with QTc interval prolongation, after adjusting confounding factors, only abdominal obesity[OR = 2.76,95 % CI（1.43, 7.56） ,P〈0.01] and hypertriglyeeridemia[OR= 1.75,95%CI（1.22,4.31）,P=0. 013）] were closely correlated with QTc interval prolongation. Conclusion MS is an independent risk factor of QTc interval prolongation. It is especially important to strengthen the management of blood lipid and abdominal circumference.