线粒体表观遗传修饰及药物靶点研究进展

Research progress of mitochondrial epigenetic modification and drug targets

线粒体是细胞氧化磷酸化的场所,拥有自身的遗传物质和遗传体系,属于半自主细胞器。除为细胞供能外,还参与诸如细胞分化、细胞信息传递和细胞凋亡等生命过程,并拥有调控细胞生长的能力。线粒体DNA与核DNA类似,也存在表观遗传修饰,本文对线粒体表观遗传修饰研究进展进行文献综述,对基于线粒体表观遗传发现新颖药物靶点及生物标记物具有重要意义。

Mitochondrion, an organelle of cell oxidative phosphorylation, possesses its own genetic materials and genetic systems, and is a kind of semi-autonomous organelle. In addition to providing energy for the cell, mitochondrion also participates in processes such as cell differentiation, cell information transfer, cell apoptosis, and cell growth regulation. At present, some data indicate that mitochondrial DNA belongs to epigenetic modification like nuclear DNA. In this paper, we reviewed the research on mitochondrial epigenetic modification in recent years. This modification is of great significance for the discovery of novel therapeutic targets and biomarkers based on mitochondrial epigenetic modification.