铁死亡的机制及其在神经疾病中的作用

Mechanism of ferroptosis and its role in neurological diseases

铁死亡是一种新型的细胞死亡方式,它在形态、生物化学和基因水平上,均不同于目前已知的细胞凋亡、自噬、坏死、角化和其他形式的细胞死亡。研究发现,铁死亡在神经、肿瘤等疾病中参与疾病的发生发展,并起到重要作用。阿尔茨海默病、帕金森综合征、亨廷顿舞蹈病、中风及脑室周围白质软化症等神经疾病,发病原因复杂,作用机制仍不明确。机制研究发现,铁死亡与神经疾病之间有着紧密联系,该文就铁死亡的机制及其在神经疾病发生发展过程中的作用进行综述。

Ferroptosis is distinct from apoptosis, autophagy,necrosis,cornification and other cell deaths from morphological,biochemical as well as genetic aspects. Ferroptosis plays a critical role in neurological diseases and cancers. Neurological diseases,such as Alzheimer 's disease, Parkinson 's disease,Huntington's disease,stroke,periventricular leukomalacia and so on,are characterized by multiple etiologies and mechanisms,and are potentially correlated with ferroptosis. Based on the recent researches on ferroptosis and neurological diseases,this review investigates ferroptosis and its role in neurological diseases.