不同年龄段女性医务人员人乳头瘤病毒感染现状分析

A status analysis on the HPV infection of female medical personnel of different age group

目的:调查不同年龄段的女性医务人员高危型人乳头瘤病毒(HPV)的感染现状及年龄分布,探讨HPV的针对性防治策略,为制定医院女性医务人员HPV体检方案提供依据。方法:收集医院不同年龄段的182名进行体格检查的女性医务人员的阴道分泌物标本,应用聚合酶链反应(PCR)荧光探针法进行HPV定性检测,按照不同年龄段将其分为6组,即25~30岁组、31~35岁组、36~40岁组、41~45岁组、46~50岁组和≥51岁组,统计分析6组中各不同年龄段HPV感染特征。结果:在182例标本中共检出29例感染HPV,其中高危型HPV(HR-HPV)阳性标本28例,阳性检出率为15.38%;低危型HPV(LR-HPV)阳性标本1例,阳性检出率为0.55%,两种类型检出率比较差异有统计学意义(x2=27.314,P<0.01)。HR-HPV的感染率在不同年龄组间差异无统计学意义(x2=8.812,P>0.05),但不同年龄组HPV感染曲线高峰为46~50岁组(占35.00%)和36~40岁组(占24.00%)。结论:医院中女性医务人员的年龄与HR-HPV感染有一定关系,在制定宫颈癌防控方案时需将医院所有HPV感染的类型分布和各年龄段感染特征等因素纳入其中。

Objective To investigate the infection status and age distribution of human papilloma virus（HPV） of high-risk type in female medical personnel of different age groups, and discuss the pertinent control strategy, and provide basis for formulating physical examination plan of HPV for female medical personnel. Methods： The vaginal secretion samples of 182 female medical personnel in different ages who underwent physical examination were enrolled this research. Then HPV qualitative detection was performed by PCR-Fluorescent Probe Method. All of these personnel were divided into 6 groups according to different age group that included of 25-30 years old group, 31-35 years old group, 36-40 years old group, 41-45 years old group, 46-50 years old group and more than 51 years old group. The HPV infection features of different age group were analyzed as statistic method. Results： In 182 samples, there were 29 samples were infected by HPV. And among of them, 28 samples with positive high-risk HPV were found, and the positive relevance ratio was 15.38%. 1 sample with positive low-risk HPV was found, and the positive relevance ratio was 0.55%. The difference of relevance ratio between the two kinds of sample was statistically significant（x2=27.314, P〈0.01）. Among different age groups, the differences of infection rate of the high-risk HPV were no statistically significant（x2=8.812, P〉0.05）. However, the curves of HPV infection showed that there were two peaks among different age groups. One was 46-50 years old group（35.00%）, and the other was 36-40 years old group（24.00%）. Conclusion： In hospital, there is a certain relation between the age of female medical personnel and HR-HPV infection. And when the prevention strategies of cervical carcinoma is formulated, factors that covers all of HPV infection type distribution characteristics of the hospital, infection features of different ages and others should be carefully considered and brought into the analysis.