胰高血糖素样肽-1预防糖尿病并发症研究进展

Role of glucagon-like peptide-1 in the prevention of diabetic complications

胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是肠道摄入营养素后分泌的重要肠促胰岛素之一,具有促进胰岛素分泌、抑制胰岛β细胞凋亡、改善血管内皮细胞功能、促进心肌梗死后心功能恢复等多种作用。GLP-1对糖尿病微血管并发症(如视网膜病变、肾脏病变和神经病变)、大血管并发症(如冠状动脉疾病、外周动脉疾病和脑血管疾病)及合并症(如肥胖、非酒精性脂肪性肝病、骨折和认知功能障碍)具有较好的预防作用。本文就GLP-1预防糖尿病并发症的研究进展作一综述。

Glucagon-like peptide-1 （GLP-1） is one of the important incretin hormones secreted by enteral nutrient intake. GLP-1 has the functions as promoting insulin secretion, inhibiting pancreatic β-cell apoptosis, improving vascular endothelial cell function and promoting recovery after myocardial infarction. GLP-1 has a good preventive effect on diabetes-related microvascular complications （retinopathy, kidney disease and neuropathy） （coronary artery disease, peripheral arterial disease and eerebrovascular disease） and （obesity, non-alcoholic fatty liver disease, fracture and cognitive dysfunction）. This paper of GLP-1 in the prevention of diabetic complications.