右美托咪定联合舒芬太尼镇静对急性颅脑损伤开颅手术患者预后的影响

Effect of dexmedetomidine combined with sufentanil on the prognosis of craniotomy patients with acute craniocerebral injury

目的探讨右美托咪定联合舒芬太尼镇静对急性颅脑损伤开颅手术患者预后的影响。方法 80例急性颅脑损伤行开颅手术的患者作为本次研究对象,按照随机抽号的方法分为A组和B组,每组40例。A组患者静脉注入舒芬太尼药物,B组患者在A组基础上静脉注入右美托咪定药物。对比两组患者的术后镇痛效果以及预后不良反应。结果 B组患者术后6、12、24 h的活动状态痛感评分、安静状态痛感评分均低于A组,差异均具有统计学意义(P<0.05)。B组患者不良反应总发生率15.00%低于A组42.50%,差异具有统计学意义(P<0.05)。结论通过对急性颅脑损伤行开颅手术的患者静脉注入右美托咪定联合舒芬太尼药物,具有显著的镇痛效果,且能够很大程度的降低患者的不良应激反应发生率,在一定程度上保证患者的血流动力学,具有临床推广意义。

Objective To discuss the effect of dexmedetomidine combined with sufentanil on the prognosis of craniotomy patients with acute craniocerebral injury. Methods A total of 80 craniotomy patients with acute craniocerebral injury as study subjects were randomly divided into group A and group B, with 40 cases in each group. Group A received intravenous injection of sufentanil, and group B received intravenous injection of dexmedetomidine on the basis of group A. Comparison were made on postoperative analgesic effect and adverse prognosis between two groups. Results Group B had lower activity state pain score, quiet state pain score in postoperative 6, 12 and 24 h than group A, and the difference was statistically significant（P〈0.05）. Group B had lower incidence of total adverse reaction as 15.00% than 42.50% in group A, and the difference was statistically significant（P〈0.05）. Conclusion Intravenous injection of dexmedetomidine and sufentanil for craniotomy patients with acute craniocerebral injury provides remarkable analgesic effect, and can greatly reduce the incidence of patient＇s adverse stress response and ensure their hemodynamics to a certain extent. It contains clinical promotion significance.