益生菌治疗溃疡性结肠炎效果观察与研究

Observation and study of the effect of probiotics in the treatment of ulcerative colitis

目的研究并分析采用双歧杆菌四联活菌片(益生菌)治疗溃疡性结肠炎的临床效果。方法 120例溃疡性结肠炎患者,通过数字随机表法分为对照组和观察组,每组60例。对照组患者单用美沙拉嗪治疗,观察组患者采用益生菌联合美沙拉嗪治疗。观察两组患者临床疗效、复发率及不良反应发生率。结果治疗后,对照组患者总有效率为76.67%(46/60);观察组患者为93.33%(56/60)。观察组患者治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。对照组患者随访期间12例复发,复发率为20.00%(12/60);观察组患者随访期间2例复发,复发率为3.33%(2/60),观察组患者复发率明显低于对照组,差异有统计学意义(P<0.05)。对照组患者用药期间不良反应发生率为21.67%(13/60);观察组患者为3.33%(2/60),观察组患者不良反应发生率明显低于对照组(P<0.05)。结论溃疡性结肠炎患者的治疗过程中,在美沙拉嗪治疗基础上联合使用益生菌治疗能够使患者获得更加确切的疗效,能够降低用药不良反应和疾病的复发率,值得推广应用。

Objective To study and analyze the clinical effect of bifidobacterium quadruple living bacterium（probiotics） in the treatment of ulcerative colitis. Methods A total of 120 ulcerative colitis patients were divided by random number table method into control group and observation group, with 60 cases in each group. The control group was treated with mesalazine only, and the observation group was treated with probiotics and mesalazine. Observation were made on clinical efficacy, recurrence rate and incidence of adverse reactions between two groups. Results After treatment, the control group had total effective rate as 76.67%（46/60）, which was 93.33%（56/60） in the observation group. The observation group had obviously higher total treatment effective rate than the control group, and the difference was statistically significant（P〈0.05）. The control group had 12 recurrent cases during follow-up, with recurrence rate as 20.00%（12/60）, while the observation group had 2 recurrent cases during follow-up, with recurrence rate as 3.33%（2/60）. The observation group had obviously lower recurrence rate than the control group, and the difference was statistically significant（P〈0.05）. The control group had incidence of adverse reactions during administration as 21.67%（13/60）, while the observation group had incidence of adverse reactions during administration as 3.33%（2/60）. The observation group had obviously lower incidence of adverse reactions than the control group（P〈0.05）. Conclusion In the treatment of ulcerative colitis patients, application of promethazine on the basis of mesalazine can make patients get a more definite effect, reduce the adverse reactions and the recurrence rate of the disease. It is worthy of popularization and application.