软骨组织工程中骨软骨复合支架与宿主的接合界面问题研究进展

Progress in integration between osteochondral composite scaffold and host tissue： review

组织工程支架在软骨的修复中起到重要的作用，近年来骨软骨复合支架因能够起到同时修复软骨与软骨下骨的作用逐渐受到重视。骨软骨复合支架的远期稳定性与支架和宿主的接合程度相关，移植的骨软骨双相支架存在支架软骨相与宿主软骨的接合问题、支架软骨相与支架骨相的接合问题以及支架骨相与宿主软骨下骨的接合问题。本文就近年来骨软骨复合支架与移植宿主组织的接合问题进行探讨，总结骨软骨复合支架在3种接合问题上的研究进展。

Tissue engineering scaffold plays an important role in cartilage repair. In recent years, osteochondral composite scaffold has been paid more and more attention because of its ability to repair cartilage and subchondral bone at the same time. The long-term stability of the composite scaffold is related to the successful integration between the scaffold and the host. The problem of integration between the scaffold and the host can be divided into three parts： cartilage part of scaffold-host cartilage, cartilage part of scaffold-bone part of scaffold and bone part of scaffold-host subchondral bone. In this paper, the progress in integration between osteochondral composite scaffold and the host tissue will be discussed.