肝脏缺血再灌注损伤机制研究进展

Mechanism and progress of hepatic ischemia reperfusion injury

肝脏缺血再灌注损伤（HIRI）是一个多因素参与、共同作用的复杂病理生理过程，直接关系到临床预后，深入探讨HIRI病理生理变化及机制，制订合理的干预治疗策略，努力提高患者预后，一直备受国内外学者研究关注。研究证实，HIRI的发生机制与代谢性酸中毒、钙超载、氧自由基、细胞凋亡、内皮素及一氧化氮浓度的失衡、补体系统、黄嘌呤氧化酶、热休克蛋白、Küpffer细胞、淋巴细胞及中性粒细胞的活化等众多因素有关。

Hepatic ischemia reperfusion injury （HIRI） is a complex pathophysiological process involving multiple factors. It is directly associated with the clinical prognosis. In order to develop reasonable intervention strategies and to improve the prognosis of patients with HIRI, more and more attention has been paid by researchers to investigate the pathophysiological changes and mechanisms of HIRI. A large number of studies have confirmed that the mechanisms of HIRI are involved in metabolic acidosis, calcium overload, oxygen free radicals, apoptosis, endothelin and nitric oxide concentration imbalance, complement, xanthine oxidase, heat shock protein, Küpffer cells, lymphocytes and neutrophils activation and many other factors. It is critical for clinical intervention of HIRI to further explore its mechanism.