探讨兰索拉唑、奥曲肽、血凝酶三药联用治疗老年急性上消化道出血的疗效

Investigation on the efficacy of lansoprazole combined with octreotide and hemagglutinin in the treatment of acute upper gastrointestinal bleeding in the elderly

目的分析兰索拉唑、奥曲肽、血凝酶三药联用治疗老年急性上消化道出血的疗效。方法 70例老年急性上消化道出血患者,采取随机抽签的方式分为治疗组和对照组,每组35例。两组患者均行支持治疗,在此基础上治疗组患者采用兰索拉唑、奥曲肽、血凝酶三药联合治疗,对照组患者单用兰索拉唑治疗。比较两组患者治疗效果、止血时间、腹痛缓解时间、血压稳定时间、胃管引流量及不良反应发生情况。结果治疗组患者治疗总有效率为94.3%,高于对照组的71.4%,差异具有统计学意义(χ2=4.953,P<0.05)。治疗组患者止血时间、腹痛缓解时间、血压稳定时间均短于对照组,胃管引流量少于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(χ2=0.159,P>0.05)。结论兰索拉唑、奥曲肽、血凝酶三药联用治疗老年急性上消化道出血疗效确切、起效迅速、安全性高。

Objective To analyze the efficacy of lansoprazole combined with octreotide and hemagglutinin in the treatment of acute upper gastrointestinal bleeding in the elderly. Methods A total of 70 elderly patients with acute upper gastrointestinal bleeding were divided by random lottery method into treatment group and control group, with 35 cases in each group. Both groups received support therapy, and the treatment group also received lansoprazole combined with octreotide and hemagglutinin for treatment. The control group also received lansoprazole for treatment. Comparison were made on treatment effect, hemostasis time, remission time of abdominal pain, blood pressure stabilization time, gastric tube drainage and occurrence of adverse reactions between two groups. Results The treatment group had higher total treatment effective rate as 94.3% than 71.4% in the control group, and the difference was statistically significant （χ^2=4.953, P〈0.05）. The treatment group had shorter hemostasis time, remission time of abdominal pain, blood pressure stabilization time than the control group, and less gastric tube drainage than the control group. Their difference was statistically significant （P〈0.05）. Both groups had no statistically significant difference in incidence of adverse reactions （χ^2=0.159, P〉0.05）. Conclusion Combination of lansoprazole, octreotide and hemagglutinin shows affirmative efficacy, rapid onset and high safety for the treatment of acute upper gastrointestinal bleeding in the elderly.